The influence of body mass index on biomarkers of cellular senescence in older adults

The Journals of Gerontology Series A: Biological Sciences and Medical Sciences Pub Date : 2024-10-24 DOI:10.1093/gerona/glae251

Allyson K Palmer, Jennifer St. Sauver, Roger A Fielding, Elizabeth Atkinson, Thomas A White, Michaela McGree, Susan Weston, Nathan K LeBrasseur

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Abstract

Obesity accelerates the onset and progression of age-related conditions. In preclinical models, obesity drives cellular senescence, a cell fate that compromises tissue health and function, in part through a robust and diverse secretome. In humans, components of the secretome have been used as senescence biomarkers that are predictive of age-related disease, disability, and mortality. Here, using biospecimens and clinical data from two large and independent cohorts of older adults, we tested the hypothesis that the circulating concentrations of senescence biomarkers are influenced by body mass index (BMI). After adjusting for age, sex, and race, we observed significant increases in activin A, Fas, MDC, PAI1, PARC, TNFR1, and VEGFA, and a significant decrease in RAGE, from normal weight, to overweight, to obesity BMI categories by linear regression in both cohorts (all p < 0.05). These results highlight the influence of BMI on circulating concentrations of senescence biomarkers.

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体重指数对老年人细胞衰老生物标志物的影响

肥胖会加速衰老相关疾病的发生和发展。在临床前模型中，肥胖会导致细胞衰老，这种细胞命运会损害组织的健康和功能，部分原因是肥胖会导致分泌组的强大和多样化。在人体中，分泌组的成分被用作衰老生物标志物，可预测与年龄相关的疾病、残疾和死亡率。在这里，我们利用来自两个独立的大型老年人队列的生物样本和临床数据，检验了衰老生物标志物的循环浓度受体重指数（BMI）影响的假设。在对年龄、性别和种族进行调整后，通过线性回归，我们观察到在两个队列中，从正常体重、超重到肥胖的 BMI 类别中，活化素 A、Fas、MDC、PAI1、PARC、TNFR1 和 VEGFA 均显著增加，而 RAGE 则显著减少（所有 p < 0.05）。这些结果凸显了体重指数对衰老生物标志物循环浓度的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

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