Cancer Prevalence across Vertebrates

IF 29.7 1区 医学 Q1 ONCOLOGY Cancer discovery Pub Date : 2024-10-24 DOI:10.1158/2159-8290.cd-24-0573
Zachary T. Compton, Walker Mellon, Valerie K. Harris, Shawn Rupp, Diego Mallo, Stefania E. Kapsetaki, Mallory Wilmot, Ryan Kennington, Kathleen Noble, Cristina Baciu, Lucia N. Ramirez, Ashley Peraza, Brian Martins, Sushil Sudhakar, Selin Aksoy, Gabriela Furukawa, Orsolya Vincze, Mathieu Giraudeau, Elizabeth G. Duke, Simon Spiro, Edmund Flach, Hannah Davidson, Christopher I. Li, Ashley Zehnder, Trevor A. Graham, Brigid V. Troan, Tara M. Harrison, Marc Tollis, Joshua D. Schiffman, C. Athena Aktipis, Lisa M. Abegglen, Carlo C. Maley, Amy M. Boddy
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Abstract

Cancer is pervasive across multicellular species, but what explains the differences in cancer prevalence across species? Using 16,049 necropsy records for 292 species spanning three clades of tetrapods (amphibians, sauropsids, and mammals), we found that neoplasia and malignancy prevalence increases with adult mass (contrary to Peto’s paradox) and somatic mutation rate but decreases with gestation time. The relationship between adult mass and malignancy prevalence was only apparent when we controlled for gestation time. Evolution of cancer susceptibility appears to have undergone sudden shifts followed by stabilizing selection. Outliers for neoplasia prevalence include the common porpoise (<1.3%), the Rodrigues fruit bat (<1.6%), the black-footed penguin (<0.4%), ferrets (63%), and opossums (35%). Discovering why some species have particularly high or low levels of cancer may lead to a better understanding of cancer syndromes and novel strategies for the management and prevention of cancer. Significance: Evolution has discovered mechanisms for suppressing cancer in a wide variety of species. By analyzing veterinary necropsy records, we can identify species with exceptionally high or low cancer prevalence. Discovering the mechanisms of cancer susceptibility and resistance may help improve cancer prevention and explain cancer syndromes.
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脊椎动物的癌症发病率
癌症在多细胞物种中普遍存在,但不同物种的癌症发病率有何差异?通过对横跨四足动物三个支系(两栖类、梭形类和哺乳类)的 292 个物种的 16,049 份尸检记录进行分析,我们发现肿瘤和恶性肿瘤的发病率随着成体质量(与佩托悖论相反)和体细胞突变率的增加而增加,但随着妊娠时间的延长而减少。只有当我们控制了妊娠时间后,成体质量与恶性肿瘤发病率之间的关系才变得明显。癌症易感性的进化似乎经历了突然的转变,然后是稳定的选择。肿瘤发病率的异常值包括普通鼠海豚(<1.3%)、罗德里格斯果蝠(<1.6%)、黑脚企鹅(<0.4%)、雪貂(63%)和负鼠(35%)。发现某些物种癌症发病率特别高或特别低的原因,可能有助于更好地了解癌症综合征,并制定新的癌症管理和预防策略。意义重大:进化发现了各种物种抑制癌症的机制。通过分析兽医尸检记录,我们可以确定癌症发病率特别高或特别低的物种。发现癌症易感性和抵抗力的机制可能有助于改善癌症预防和解释癌症综合症。
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来源期刊
Cancer discovery
Cancer discovery ONCOLOGY-
CiteScore
22.90
自引率
1.40%
发文量
838
审稿时长
6-12 weeks
期刊介绍: Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.
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