{"title":"Anion Recognition-Directed Supramolecular Catalysis with Functional Macrocycles and Molecular Cages","authors":"Qi-Qiang Wang","doi":"10.1021/acs.accounts.4c00583","DOIUrl":null,"url":null,"abstract":"The development of supramolecular chemistry has provided a variety of host molecules and noncovalent tools for boosting catalytic processes, stimulating the emergence and advance of supramolecular catalysis, among which macrocyclic and cage-like compounds have attracted great attention due to their possession of an enzyme-mimetic cavity and recognition ability. While the privileged scaffolds such as crown ethers, cyclodextrins, cucurbiturils, calixarenes, and metal-coordinated cages have been widely used, their skeletons usually do not contain a directional binding site; binding and activation mainly rely on cation-associated interactions or hydrophobic effects. In this context, the recent advance of anion supramolecular chemistry has drawn our attention to developing an anion recognition-directed approach by using tailor-made functionalized macrocycles and cages. Anions are important widely existing species in both biological and chemical systems and play an important role in regulating the structure and function of enzymes. We envisioned that by taking advantage of anions, including their rich variety, diverse geometry, and multiple interaction sites, the sophisticated cooperation of multiple noncovalent interactions can be manipulated in a confined cavity for directing efficient and selective catalysis.","PeriodicalId":1,"journal":{"name":"Accounts of Chemical Research","volume":null,"pages":null},"PeriodicalIF":16.4000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Accounts of Chemical Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1021/acs.accounts.4c00583","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
The development of supramolecular chemistry has provided a variety of host molecules and noncovalent tools for boosting catalytic processes, stimulating the emergence and advance of supramolecular catalysis, among which macrocyclic and cage-like compounds have attracted great attention due to their possession of an enzyme-mimetic cavity and recognition ability. While the privileged scaffolds such as crown ethers, cyclodextrins, cucurbiturils, calixarenes, and metal-coordinated cages have been widely used, their skeletons usually do not contain a directional binding site; binding and activation mainly rely on cation-associated interactions or hydrophobic effects. In this context, the recent advance of anion supramolecular chemistry has drawn our attention to developing an anion recognition-directed approach by using tailor-made functionalized macrocycles and cages. Anions are important widely existing species in both biological and chemical systems and play an important role in regulating the structure and function of enzymes. We envisioned that by taking advantage of anions, including their rich variety, diverse geometry, and multiple interaction sites, the sophisticated cooperation of multiple noncovalent interactions can be manipulated in a confined cavity for directing efficient and selective catalysis.
期刊介绍:
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.