Ujjwal Karmakar, Jaehan Bae, Jin A Kim, Seoyeon Kim, Won-Geun Yang, Eun Jin Cho
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引用次数: 0
Abstract
The reactivity of allenes has historically been limited with no previous examples of their hydroalkylation using diazo compounds in any transition-metal catalytic framework. In this study, we present a Ni-catalyzed regio- and stereoselective hydroalkylation reaction of allenes utilizing diazo compounds as alkylating agents. The success of this method can be attributed to the use of a pyridine-based P,N ligand, which combines the advantages of both phosphine and nitrogen ligands. Additionally, the carbonyl group in the diazo compound facilitates the formation of stable intermediates. Our detailed mechanistic studies reveal that the reaction proceeds through an initial interaction with the diazo compound, followed by engagement with the allene.
期刊介绍：
ACS Catalysis is an esteemed journal that publishes original research in the fields of heterogeneous catalysis, molecular catalysis, and biocatalysis. It offers broad coverage across diverse areas such as life sciences, organometallics and synthesis, photochemistry and electrochemistry, drug discovery and synthesis, materials science, environmental protection, polymer discovery and synthesis, and energy and fuels.
The scope of the journal is to showcase innovative work in various aspects of catalysis. This includes new reactions and novel synthetic approaches utilizing known catalysts, the discovery or modification of new catalysts, elucidation of catalytic mechanisms through cutting-edge investigations, practical enhancements of existing processes, as well as conceptual advances in the field. Contributions to ACS Catalysis can encompass both experimental and theoretical research focused on catalytic molecules, macromolecules, and materials that exhibit catalytic turnover.
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