Molecular and cellular dynamics of squamous cell carcinomas across tissues

IF 7.5 1区 生物学 Q1 CELL BIOLOGY Genes & development Pub Date : 2024-10-25 DOI:10.1101/gad.351990.124
Matthew R. Kudelka, Yonit Lavin, Siman Sun, Elaine Fuchs
{"title":"Molecular and cellular dynamics of squamous cell carcinomas across tissues","authors":"Matthew R. Kudelka, Yonit Lavin, Siman Sun, Elaine Fuchs","doi":"10.1101/gad.351990.124","DOIUrl":null,"url":null,"abstract":"Squamous cell carcinomas (SCCs), arising from the skin, head and neck, lungs, esophagus, and cervix, are collectively among the most common cancers and a frequent cause of cancer morbidity and mortality. Despite distinct stratified epithelial tissues of origin, converging evidence points toward shared biologic pathways across SCCs. With recent breakthroughs in molecular technologies have come novel SCC treatment paradigms, including immunotherapies and targeted therapy. This review compares commonalities and differences across SCCs from different anatomical sites, including risk factors and genetics, as well as cellular and molecular programs driving tumorigenesis. We review landmark discoveries of the “cancer stem cells” (CSCs) that initiate and propagate SCCs and their gene and translational regulation programs. This has led to an appreciation that interactions between CSCs and the immune system play key roles in invasion and therapeutic resistance. Here, we review the unifying principles of SCCs that have emerged from these exciting advances in our understanding of these epithelial cancers.","PeriodicalId":12591,"journal":{"name":"Genes & development","volume":null,"pages":null},"PeriodicalIF":7.5000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Genes & development","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1101/gad.351990.124","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Squamous cell carcinomas (SCCs), arising from the skin, head and neck, lungs, esophagus, and cervix, are collectively among the most common cancers and a frequent cause of cancer morbidity and mortality. Despite distinct stratified epithelial tissues of origin, converging evidence points toward shared biologic pathways across SCCs. With recent breakthroughs in molecular technologies have come novel SCC treatment paradigms, including immunotherapies and targeted therapy. This review compares commonalities and differences across SCCs from different anatomical sites, including risk factors and genetics, as well as cellular and molecular programs driving tumorigenesis. We review landmark discoveries of the “cancer stem cells” (CSCs) that initiate and propagate SCCs and their gene and translational regulation programs. This has led to an appreciation that interactions between CSCs and the immune system play key roles in invasion and therapeutic resistance. Here, we review the unifying principles of SCCs that have emerged from these exciting advances in our understanding of these epithelial cancers.
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
不同组织鳞状细胞癌的分子和细胞动态变化
鳞状细胞癌(SCC)发生于皮肤、头颈部、肺部、食道和宫颈,是最常见的癌症之一,也是癌症发病率和死亡率的常见原因。尽管起源的分层上皮组织各不相同,但越来越多的证据表明,SCCs 具有共同的生物通路。随着分子技术的不断突破,新的 SCC 治疗模式也应运而生,包括免疫疗法和靶向疗法。本综述比较了来自不同解剖部位的 SCC 的共性和差异,包括风险因素和遗传学,以及驱动肿瘤发生的细胞和分子程序。我们回顾了具有里程碑意义的发现:"癌症干细胞"(CSCs)启动并繁殖了SCCs及其基因和转化调控程序。这使人们认识到,CSCs 与免疫系统之间的相互作用在侵袭和抗药性方面发挥着关键作用。在此,我们回顾了在我们对这些上皮癌的认识上取得的这些令人兴奋的进展所产生的 SCC 的统一原则。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Genes & development
Genes & development 生物-发育生物学
CiteScore
17.50
自引率
1.90%
发文量
71
审稿时长
3-6 weeks
期刊介绍: Genes & Development is a research journal published in association with The Genetics Society. It publishes high-quality research papers in the areas of molecular biology, molecular genetics, and related fields. The journal features various research formats including Research papers, short Research Communications, and Resource/Methodology papers. Genes & Development has gained recognition and is considered as one of the Top Five Research Journals in the field of Molecular Biology and Genetics. It has an impressive Impact Factor of 12.89. The journal is ranked #2 among Developmental Biology research journals, #5 in Genetics and Heredity, and is among the Top 20 in Cell Biology (according to ISI Journal Citation Reports®, 2021).
期刊最新文献
BRCA1 and BRCA2: from cancer susceptibility to synthetic lethality Genetics and biology of pancreatic ductal adenocarcinoma Classifying the molecular functions of transcription factors beyond activation and repression. DNA-directed termination of mammalian RNA polymerase II Deciphering normal and cancer stem cell niches by spatial transcriptomics: opportunities and challenges.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1