Synthesis of di/tri-substituted carbazoles involving Pd-mediated Sonogashira coupling of indolyltriflates with aryl acetylenes†

IF 2.7 3区 化学 Q1 CHEMISTRY, ORGANIC Organic & Biomolecular Chemistry Pub Date : 2024-10-16 DOI:10.1039/d4ob01536c
Rudrasenan Agneswaran , Arasambattu K. Mohanakrishnan
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Abstract

In this study, we present our preliminary findings on the synthesis of carbazole derivatives involving the Sonogashira coupling reaction of 2-(trimethylamino)methylindolyltriflates with aryl acetylenes followed by isomerization, thermal electrocyclization and 1,3-H shift, furnishing the respective di- and tri-substituted carbazoles.

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通过钯介导的吲哚基三氟酸盐与芳基乙炔的 Sonogashira 偶联合成二/三代咔唑。
在本研究中,我们介绍了合成咔唑衍生物的初步发现,包括 2-(三甲基氨基)甲基吲哚三氟酸盐与芳基乙炔的 Sonogashira 偶联反应,然后进行异构化、热电环化和 1,3-H 变换,得到相应的二取代咔唑和三取代咔唑。
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来源期刊
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry 化学-有机化学
CiteScore
5.50
自引率
9.40%
发文量
1056
审稿时长
1.3 months
期刊介绍: Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
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