Risk and timing of postpartum depression in parents of twins compared to parents of singletons.

IF 5.3 2区 医学 Q1 PSYCHIATRY Acta Psychiatrica Scandinavica Pub Date : 2024-10-25 DOI:10.1111/acps.13766
Sofie Egsgaard, Mette Bliddal, Lars Christian Lund, Simone N Vigod, Trine Munk-Olsen
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Abstract

Background: Parents of twins appear to be at increased risk of postpartum depression (PPD), yet little is known about the magnitude and timing of onset in the postpartum period compared to singleton parents.

Methods: We conducted a cohort study using the Danish nationwide health registers. We defined a study population of parents that is, mothers and fathers of all twin and singleton livebirths between 1997 and 2019. Postpartum depression was defined as incident depression diagnosis or a redeemed antidepressant prescription from childbirth through 365 days postpartum. We performed a parametric time-to-event analysis based on Poisson regression. The time scale was time since birth, modeled using restricted cubic splines. From this we estimated the hazard ratio (HR) representing the momentary risk, and the cumulative risk ratio (RR) over the first year postpartum, in twin compared to singleton parents.

Results: The study population was based on 27,095 twin and 1,350,046 singleton births. In adjusted analyses, the HR of twins compared to singletons was highest around 2 months postpartum (HR 1.28, 95% CI 1.10-1.49) for mothers, and around 6 months (1.20, 95% CI 1.02-1.42) for fathers. The 6 months adjusted cumulative RR of PPD in twins compared to singletons was 1.24 (95% CI 1.10-1.40) for mothers and 1.11 (95% CI 0.95-1.30) for fathers.

Conclusions: Twin mothers had increased risk of PPD compared to singleton mothers, which was driven by an immediate increase after childbirth. The risk among twin fathers was not increased immediately after childbirth, but we found slightly elevated risk around 6 months postpartum. This could suggest diverse patterns of PPD symptomatology in twin parents compared to singleton parents and between mothers and fathers. Our findings underline parents of twins as a potentially vulnerable group to PPD and emphasize the need for increased awareness of their mental health.

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与单胎父母相比,双胞胎父母产后抑郁的风险和时间。
背景:双胞胎父母患产后抑郁症(PPD)的风险似乎更高,但与单胎父母相比,人们对双胞胎父母产后抑郁症的程度和发病时间知之甚少:我们利用丹麦全国健康登记册进行了一项队列研究。方法:我们利用丹麦全国健康登记册进行了一项队列研究。我们定义了一个父母研究人群,即 1997 年至 2019 年间所有双胞胎和单胎活产婴儿的母亲和父亲。产后抑郁症的定义是:从分娩到产后 365 天内,诊断出抑郁症或开具过抗抑郁药处方。我们在泊松回归的基础上进行了参数时间事件分析。时间尺度为出生后的时间,使用受限立方样条进行建模。由此,我们估算出了双胎父母与单胎父母相比,代表瞬间风险的危险比(HR)和产后第一年的累积风险比(RR):研究对象包括 27,095 名双胞胎和 1,350,046 名单胎。在调整分析中,双胞胎与单胎相比,母亲在产后 2 个月左右的 HR 最高(HR 1.28,95% CI 1.10-1.49),父亲在产后 6 个月左右的 HR 最高(1.20,95% CI 1.02-1.42)。双胞胎与单胎相比,母亲患 PPD 的 6 个月调整累积 RR 为 1.24(95% CI 1.10-1.40),父亲为 1.11(95% CI 0.95-1.30):与单胎母亲相比,双胞胎母亲罹患PPD的风险更高,这主要是由于分娩后罹患PPD的风险立即增加。双胞胎父亲的风险在产后没有立即增加,但我们发现在产后6个月左右风险略有增加。这可能表明,与单胎父母相比,双胞胎父母以及母亲和父亲之间的 PPD 症状模式各不相同。我们的研究结果强调了双胞胎父母是潜在的 PPD 易感人群,并强调需要提高对他们心理健康的认识。
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来源期刊
Acta Psychiatrica Scandinavica
Acta Psychiatrica Scandinavica 医学-精神病学
CiteScore
11.20
自引率
3.00%
发文量
135
审稿时长
6-12 weeks
期刊介绍: Acta Psychiatrica Scandinavica acts as an international forum for the dissemination of information advancing the science and practice of psychiatry. In particular we focus on communicating frontline research to clinical psychiatrists and psychiatric researchers. Acta Psychiatrica Scandinavica has traditionally been and remains a journal focusing predominantly on clinical psychiatry, but translational psychiatry is a topic of growing importance to our readers. Therefore, the journal welcomes submission of manuscripts based on both clinical- and more translational (e.g. preclinical and epidemiological) research. When preparing manuscripts based on translational studies for submission to Acta Psychiatrica Scandinavica, the authors should place emphasis on the clinical significance of the research question and the findings. Manuscripts based solely on preclinical research (e.g. animal models) are normally not considered for publication in the Journal.
期刊最新文献
Issue Information Variation of subclinical psychosis as a function of population density across different European settings: Findings from the multi-national EU-GEI study. Risk and timing of postpartum depression in parents of twins compared to parents of singletons. Digital phenotyping in bipolar disorder: Using longitudinal Fitbit data and personalized machine learning to predict mood symptomatology. The risk of diabetes and HbA1c deterioration during antipsychotic drug treatment: A Danish two-cohort study among patients with first-episode schizophrenia.
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