Association Between Early-Life and Premorbid Measurements of Body Composition and Risk of Motor Neuron Disease: A Prospective Cohort Study in the UK Biobank.

IF 8.1 1区医学 Q1 CLINICAL NEUROLOGY Annals of Neurology Pub Date : 2024-10-25 DOI:10.1002/ana.27109

Emily E Joyce, Shishi Xu, Caroline Ingre, Rosa Luisa Potenza, Christina Seitz, Huazhen Yang, Yu Zeng, Huan Song, Fang Fang

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Abstract

Objective: The objective of this study was to investigate the association between developmental and premorbid body composition measurements and the risk of motor neuron disease (MND).

Methods: We performed a cohort study in the UK Biobank to assess the association of developmental body metrics and premorbid body composition measures (using 28 measurements and 7 patterns of body composition) with the risk of MND. Among participants with longitudinal measures, we compared the changes in body composition over time between individuals who later developed MND and those who remained free of MND.

Results: Among the 412,691 individuals included in this study, 549 people received an MND diagnosis during the follow-up visit. Higher birth weight was associated with an increased risk of MND among individuals born over 4 kg (hazard ratio [HR] per kg increase = 2.21, 95% confidence interval [CI] = 1.38-3.55), and taller adult height was associated with an increased risk of MND (HR per 5 cm increase = 1.10, 95% CI = 1.03-1.17). We observed that measures of elevated fat mass were associated with a lower risk of MND more than 5 years before diagnosis. A higher "leg-dominant fat distribution" pattern was associated with an increased risk whereas higher "muscle strength" was associated with a reduced risk of MND 5 years before diagnosis. Longitudinal analyses indicated a faster decline in measures of fat mass and muscle strength, as well as a shift in fat distribution from arm to leg dominant, among individuals who later developed MND, compared with others.

Interpretation: Body composition at early and middle age may be indicative of the risk of MND development. ANN NEUROL 2024.

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生命早期和病前身体成分测量值与运动神经元疾病风险之间的关系：英国生物库前瞻性队列研究》。

研究目的本研究旨在调查发育期和病前身体成分测量与运动神经元疾病（MND）风险之间的关系：我们在英国生物库中进行了一项队列研究，以评估发育期身体指标和病前身体成分测量（采用 28 种测量方法和 7 种身体成分模式）与 MND 风险之间的关系。在进行了纵向测量的参与者中，我们比较了后来患上MND的人和没有患上MND的人的身体成分随时间的变化：在这项研究的 412,691 名参与者中，有 549 人在随访期间确诊为 MND。出生时体重超过4千克的人患MND的风险较高（每增加1千克的危险比[HR]=2.21，95%置信区间[CI]=1.38-3.55），成人身高较高的人患MND的风险较高（每增加5厘米的危险比[HR]=1.10，95%置信区间[CI]=1.03-1.17）。我们观察到，脂肪量升高与确诊前5年以上罹患MND的风险降低有关。较高的 "腿部脂肪分布 "模式与风险增加有关，而较高的 "肌肉力量 "则与确诊前5年MND风险降低有关。纵向分析表明，与其他人相比，后来患上MND的人的脂肪量和肌肉力量下降得更快，脂肪分布也从以手臂为主转向以腿部为主：解释：早年和中年的身体成分可能预示着MND的发病风险。ann neurol 2024.

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.