Use of e-cigarettes, traditional combustible cigarettes, and high sensitivity C-reactive protein: The Cross Cohort Collaboration

IF 3.4 2区医学 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS American heart journal Pub Date : 2025-02-01 Epub Date: 2024-10-24 DOI:10.1016/j.ahj.2024.10.012

Zhiqi Yao MD, ScM , Erfan Tasdighi MD , Zeina A. Dardari MS , John Erhabor MD, MPH , Kunal K. Jha MD , Ngozi Osuji MD, MPH , Tanuja Rajan MD, MPH , Ellen Boakye MD, MPH , Carlos J. Rodriguez MD, MPH , Joao A.C. Lima MD, MBA , Suzanne E. Judd PhD , Theodore Feldman MD , Jonathan A. Fialkow MD , Ramachandran S. Vasan MD , Omar El Shahawy PhD , Emelia J. Benjamin MD, ScM , Aruni Bhatnagar PhD , Andrew P. DeFilippis MD, MSc , Khurram Nasir MD, MPH , Michael J. Blaha MD, MPH

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Abstract

This cross-sectional study included 18,797 participants from 6 longitudinal cohorts (CARDIA, FHS Gen III, HCHS/SOL, MESA, MiHeart, and REGARDS), and 5,806 of them had high-sensitivity C-reactive protein (hs-CRP) measurements. We found that exclusive electronic cigarette (EC) use was associated with significantly lower hs-CRP levels compared to exclusive combustible cigarette use, suggesting a potentially lower inflammatory burden. hs-CRP levels in dual users and former smokers currently using EC were comparable to those observed in exclusive cigarette smokers. Exclusive EC users showed no significant difference in hs-CRP levels compared to never cigarette smokers. These findings have important implications for tobacco regulation, public health, and clinical practice, highlighting the need for continued monitoring of potential EC-related health impacts.

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使用电子烟、传统香烟与 C 反应蛋白：交叉队列协作。

这项横断面研究包括来自六个纵向队列（CARDIA、FHS Gen III、HCHS/SOL、MESA、MiHeart 和 REGARDS）的 18,797 名参与者。其中 5806 人进行了高敏 C 反应蛋白（hs-CRP）测量。我们发现，与只使用可燃卷烟相比，只使用电子烟（EC）的人的高敏C反应蛋白（hs-CRP）水平明显较低，这表明其炎症负担可能较低。与此相反，只使用电子烟的人与从不吸烟的人相比，hs-CRP水平没有明显差异。这些研究结果对烟草监管、公共卫生和临床实践具有重要意义，强调了持续监测与EC相关的健康影响的必要性。

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来源期刊

American heart journal 医学-心血管系统

CiteScore

8.20

自引率

2.10%

发文量

214

审稿时长

38 days

期刊介绍： The American Heart Journal will consider for publication suitable articles on topics pertaining to the broad discipline of cardiovascular disease. Our goal is to provide the reader primary investigation, scholarly review, and opinion concerning the practice of cardiovascular medicine. We especially encourage submission of 3 types of reports that are not frequently seen in cardiovascular journals: negative clinical studies, reports on study designs, and studies involving the organization of medical care. The Journal does not accept individual case reports or original articles involving bench laboratory or animal research.