Shevon N Alexander, Audrey R Green, Emily K Debner, Lindsey E Ramos Freitas, Hanna M K Abdelhadi, Thomas A Szabo-Pardi, Michael D Burton
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引用次数: 0
Abstract
With the National Institutes of Health's mandate to consider sex as a biological variable (SABV), there has been a significant increase of studies utilizing both sexes. Historically, we have known that biological sex and hormones influence immunological processes and now studies focusing on interactions between the immune, endocrine, and nervous systems are revealing sex differences that influence pain behavior and various molecular and biochemical processes. Neuroendocrine-immune interactions represent a key integrative discipline that will reveal critical processes in each field as it pertains to novel mechanisms in sex differences and necessary therapeutics. Here we appraise preclinical and clinical literature to discuss these interactions and key pathways that drive cell- and sex-specific differences in immunity, pain, and physiology.
随着美国国立卫生研究院（National Institutes of Health）授权将性别视为一种生物变量（SABV），利用两性进行的研究大幅增加。从历史上看，我们已经知道生物性别和激素会影响免疫过程，而现在侧重于免疫、内分泌和神经系统之间相互作用的研究则揭示了影响疼痛行为及各种分子和生化过程的性别差异。神经内分泌-免疫相互作用是一门关键的综合性学科，它将揭示每个领域的关键过程，因为它涉及到性别差异的新机制和必要的治疗方法。在此，我们对临床前和临床文献进行评估，讨论这些相互作用以及驱动免疫、疼痛和生理学中细胞和性别特异性差异的关键途径。
期刊介绍：
Biology of Sex Differences is a unique scientific journal focusing on sex differences in physiology, behavior, and disease from molecular to phenotypic levels, incorporating both basic and clinical research. The journal aims to enhance understanding of basic principles and facilitate the development of therapeutic and diagnostic tools specific to sex differences. As an open-access journal, it is the official publication of the Organization for the Study of Sex Differences and co-published by the Society for Women's Health Research.
Topical areas include, but are not limited to sex differences in: genomics; the microbiome; epigenetics; molecular and cell biology; tissue biology; physiology; interaction of tissue systems, in any system including adipose, behavioral, cardiovascular, immune, muscular, neural, renal, and skeletal; clinical studies bearing on sex differences in disease or response to therapy.
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