Demographic Characteristics and Survival in Young-Onset Colorectal Neuroendocrine Neoplasms.

IF 3.9 3区工程技术 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomedicines Pub Date : 2024-10-21 DOI:10.3390/biomedicines12102411

Deepak Vadehra, Sahithi Sonti, Beas Siromoni, Mrinalini Ramesh, Debduti Mukhopadhyay, Adrienne Groman, Renuka Iyer, Sarbajit Mukherjee

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Abstract

Background/objectives: Recent epidemiological studies have revealed an upward trend in young-onset colorectal cancer (YOCRC) overall, whereas specific data on young-onset colorectal neuroendocrine neoplasms (YONEN) remain limited. This study investigated the demographic characteristics and survival trends in YONEN and compared these with those of young-onset colorectal adenocarcinoma (YOADC), the most common histologic subtype of YOCRC.

Methods: A retrospective analysis was conducted from 2000 to 2019 using the Surveillance, Epidemiology, and End Results (SEER) database. Survival outcomes were assessed using univariate and multivariable Cox proportional models, with demographic differences evaluated via Wilcoxon rank sum and Chi-square tests.

Results: Out of 61,705 patients aged 20-49 with colorectal cancer, 8% had NEN, and 92% had adenocarcinoma. The YONEN cohort had a higher proportion of Black patients and a lower proportion of White patients than the YOADC cohort (21% vs. 13% and 44% vs. 57%, respectively). NEN was more commonly found in the rectum (79%), and adenocarcinoma was mostly colonic (57%) in origin. YONEN patients had better survival than YOADC patients. Multivariate analysis in YONEN patients revealed that Hispanic patients had better overall survival compared to White patients (HR 0.67, 95% CI 0.47-0.95, p = 0.024).

Conclusions: Racial disparities should be investigated further to aid in policymaking and targeted interventions.

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年轻发病结直肠神经内分泌肿瘤的人口统计学特征与存活率

背景/目的：最近的流行病学研究显示，年轻发病结直肠癌（YOCRC）总体呈上升趋势，而年轻发病结直肠神经内分泌肿瘤（YONEN）的具体数据仍然有限。本研究调查了幼发大肠神经内分泌瘤的人口统计学特征和生存趋势，并将其与幼发大肠腺癌（YOCRC 中最常见的组织学亚型）的人口统计学特征和生存趋势进行了比较：利用监测、流行病学和最终结果（SEER）数据库对 2000 年至 2019 年期间的数据进行了回顾性分析。采用单变量和多变量考克斯比例模型评估生存结果，并通过Wilcoxon秩和检验和Chi-square检验评估人口统计学差异：在61705名20-49岁的结直肠癌患者中，8%患有NEN，92%患有腺癌。与YOADC队列相比，YONEN队列中黑人患者比例较高，白人患者比例较低（分别为21%对13%和44%对57%）。直肠癌多见于直肠（79%），腺癌多为结肠癌（57%）。YONEN患者的生存率高于YOADC患者。对YONEN患者进行的多变量分析显示，与白人患者相比，西班牙裔患者的总生存率更高（HR 0.67，95% CI 0.47-0.95，P = 0.024）：结论：应进一步调查种族差异，以帮助制定政策和采取有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedicines Biochemistry, Genetics and Molecular Biology-General Biochemistry,Genetics and Molecular Biology

CiteScore

5.20

自引率

8.50%

发文量

2823

审稿时长

8 weeks

期刊介绍： Biomedicines (ISSN 2227-9059; CODEN: BIOMID) is an international, scientific, open access journal on biomedicines published quarterly online by MDPI.