Astragalus membranaceus: A Traditional Chinese Medicine with Multifaceted Impacts on Breast Cancer Treatment.

IF 4.8 2区 生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Biomolecules Pub Date : 2024-10-21 DOI:10.3390/biom14101339
Zhong Tang, Xuefei Tian
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Abstract

Breast cancer, the most prevalent malignant tumor among women globally, remains a critical area of focus for researchers striving to refine therapeutic approaches. As an important component of traditional Chinese medicine, Astragalus membranaceus (AM) has demonstrated potential for multifaceted impacts on breast cancer treatment through various mechanisms. To guide clinical practice and further explore the under-researched field of AM in breast cancer treatment, this paper mainly reviews the regulatory roles of AM-derived compounds and extracts on breast cancer cell proliferation, migration, invasion, and chemoresistance. Furthermore, this study delves into the synergistic effects observed when AM is co-administered with chemotherapeutic agents, including the enhancement of chemosensitivity, mitigation of toxic side effects, and reversal of drug resistance. This review indicates that AM holds promise not only as a therapy in breast cancer treatment but also paves the way for innovative integrated treatment approaches that combine the benefits of traditional medicine with modern pharmaceuticals. Nevertheless, future research endeavors are also urged to elucidate the in vivo pharmacological effects and underlying mechanisms of AM to inform more effective clinical treatment strategies.

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黄芪:对乳腺癌治疗具有多方面影响的传统中药。
乳腺癌是全球女性发病率最高的恶性肿瘤,一直是研究人员努力完善治疗方法的重点领域。作为传统中药的重要组成部分,黄芪(AM)通过各种机制对乳腺癌治疗产生了多方面的潜在影响。为了指导临床实践并进一步探索研究不足的 AM 在乳腺癌治疗中的作用,本文主要综述了 AM 衍生化合物和提取物对乳腺癌细胞增殖、迁移、侵袭和化疗耐受性的调控作用。此外,本研究还深入探讨了 AM 与化疗药物联合应用时的协同效应,包括增强化疗敏感性、减轻毒副作用和逆转耐药性。本综述表明,AM 不仅有望成为乳腺癌治疗的一种疗法,还为结合传统医学和现代药物优势的创新综合治疗方法铺平了道路。然而,未来的研究工作还需要阐明 AM 的体内药理作用和内在机制,以便为更有效的临床治疗策略提供依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomolecules
Biomolecules Biochemistry, Genetics and Molecular Biology-Molecular Biology
CiteScore
9.40
自引率
3.60%
发文量
1640
审稿时长
18.28 days
期刊介绍: Biomolecules (ISSN 2218-273X) is an international, peer-reviewed open access journal focusing on biogenic substances and their biological functions, structures, interactions with other molecules, and their microenvironment as well as biological systems. Biomolecules publishes reviews, regular research papers and short communications.  Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.
期刊最新文献
Correction: Balkrishna et al. Application of Zebrafish Model in the Suppression of Drug-Induced Cardiac Hypertrophy by Traditional Indian Medicine Yogendra Ras. Biomolecules 2020, 10, 600. Astragalus membranaceus: A Traditional Chinese Medicine with Multifaceted Impacts on Breast Cancer Treatment. Correction: Choi et al. β-Ionone Attenuates Dexamethasone-Induced Suppression of Collagen and Hyaluronic Acid Synthesis in Human Dermal Fibroblasts. Biomolecules 2021, 11, 619. tRNA and tsRNA: From Heterogeneity to Multifaceted Regulators. Cooperative Substructure and Energetics of Allosteric Regulation of the Catalytic Core of the E3 Ubiquitin Ligase Parkin by Phosphorylated Ubiquitin.
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