Postoperative opioid use in Norway-a population-based observational study on patterns of long-term use.

IF 2.8 3区 医学 Q2 PHARMACOLOGY & PHARMACY BMC Pharmacology & Toxicology Pub Date : 2024-10-25 DOI:10.1186/s40360-024-00805-y
Sara Magelssen Vambheim, Vidar Hjellvik, Ingvild Odsbu, Svetlana Skurtveit, Christopher Ekholdt, Lars Petter Granan, Audun Stubhaug, Per-Jostein Samuelsen
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Abstract

Background: The utilization patterns of opioid analgesics and the proportion of long-term opioid use after surgery in Norway is largely unknown.

Methods: This study aimed to estimate the proportion of one-year long-term prescription opioid use among all Norwegian postoperative opioid users. Complete data from central health registries (NPR, NorPD, Statistics Norway, CoDR) were linked via the personal identification number unique to all citizens. The study period was January 1st 2010 until December 31st 2019. Long-term opioid use was defined as at least two opioid dispensings within two subsequent 90-day periods, with a minimum average use of 10 MME/day for the first 90 days.

Results: The study population consisted of 693 495 post-operative opioid users (53.6% women), whereof 73.2% had not used opioids the year before surgery (new users). Among the postoperative opioid users, 3.8% were one-year long-term opioid users. The corresponding figures for new and previous opioid users were 0.4% and 13.1%, respectively. The highest proportions of long-term opioid use were found after transluminal endoscopy, eye surgery and assessments related to surgical procedures. In previous opioid users, the proportion of one-year long-term use was higher among women than men in all age groups, a difference that increased with age.

Conclusions: The proportion of postoperative long-term opioid use in Norway is generally low. We detected higher proportions of long-term opioid use after certain types of surgery, but our crude surgery definition warrants further examination. Previous opioid users pose a particular challenge in the management of postoperative pain.

Trial registration: The study used national health registry data from the period 2010-2019. A pre-registered analysis plan is available at Open Science Framework.

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挪威术后阿片类药物的使用情况--关于长期使用模式的人口观察研究。
背景:挪威的阿片类镇痛药使用模式以及术后长期使用阿片类药物的比例在很大程度上尚属未知:本研究旨在估算挪威所有术后阿片类药物使用者一年内长期使用处方阿片类药物的比例。通过所有公民独有的个人身份号码,将中央健康登记处(挪威公共卫生登记处(NPR)、挪威人口与发展部(NorPD)、挪威统计局(Statistics Norway)、CoDR)的完整数据连接起来。研究时间为 2010 年 1 月 1 日至 2019 年 12 月 31 日。长期使用阿片类药物的定义是,在随后的两个90天内至少配发过两次阿片类药物,且前90天的平均使用量至少为10毫克/天:研究对象包括 693 495 名术后阿片类药物使用者(53.6% 为女性),其中 73.2% 在手术前一年未使用过阿片类药物(新使用者)。在术后阿片类药物使用者中,3.8%是使用阿片类药物一年的长期使用者。阿片类药物新使用者和既往使用者的相应数字分别为0.4%和13.1%。长期使用阿片类药物比例最高的手术是经内窥镜手术、眼科手术和与外科手术相关的评估。在曾经使用过阿片类药物的人群中,各年龄段女性一年内长期使用阿片类药物的比例均高于男性,这一差异随着年龄的增长而增大:挪威术后长期使用阿片类药物的比例普遍较低。我们发现某些类型的手术后长期使用阿片类药物的比例较高,但我们对手术的粗略定义需要进一步研究。曾经使用过阿片类药物的患者对术后疼痛的治疗构成了特殊挑战:研究使用的是 2010-2019 年期间的国家健康登记数据。预先登记的分析计划可在开放科学框架上查阅。
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来源期刊
BMC Pharmacology & Toxicology
BMC Pharmacology & Toxicology PHARMACOLOGY & PHARMACYTOXICOLOGY&nb-TOXICOLOGY
CiteScore
4.80
自引率
0.00%
发文量
87
审稿时长
12 weeks
期刊介绍: BMC Pharmacology and Toxicology is an open access, peer-reviewed journal that considers articles on all aspects of chemically defined therapeutic and toxic agents. The journal welcomes submissions from all fields of experimental and clinical pharmacology including clinical trials and toxicology.
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