Contrast Sensitivity Is Impaired in Suspected Primary Open-Angle Glaucoma Patients.

IF 2.7 3区医学 Q3 NEUROSCIENCES Brain Sciences Pub Date : 2024-09-29 DOI:10.3390/brainsci14100993

María Constanza Tripolone, Luis Alberto Issolio, Daniel Osvaldo Perez, Pablo Alejandro Barrionuevo

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Abstract

Purpose: To assess spatial contrast sensitivity (CS) in suspected primary open-angle glaucoma (POAG) patients.

Methods: CS was measured using sinusoidal gratings of 4 cycles/degree. First, foveal and peripheral CS were assessed in 34 suspected POAG patients and compared with 71 and 28 age-matched healthy individuals for foveal and peripheral conditions, respectively. Second, foveal CS was assessed in 34 early POAG patients age-matched with suspected POAG patients. Analyses were performed considering two age ranges: Under and Over 50 y.o. Correlations were evaluated between CS and clinical parameters. Diagnostic accuracy was also analyzed.

Results: Peripheral CS was lower in older suspected POAG patients (23.4 ± 16.1) than the control group (39.1 ± 28.2) (p = 0.040). Foveal CS was reduced in suspected POAG participants (Under 50: 146.8 ± 63.3; p = 0.004. Over 50: 110.5 ± 65.0; p = 0.044) and in early POAG patients (Under 50: 141.2 ± 72.6; p = 0.002. Over 50: 80.2 ± 54.5 p < 0.001), both compared to the control group (Under 50: 213.5 ± 66.2. Over 50: 138.6 ± 71.7). CS was lower in early POAG than in POAG suspected in older patients (p = 0.042). Foveal CS was correlated with age (Early: p = 0.001. Suspect: p = 0.002) and with the cup-disc ratio only in early POAG patients (p < 0.001). Foveal CS had fair (AUC = 0.74) diagnostic accuracy for early POAG patients.

Conclusions: CS in suspected POAG patients is lower than in healthy individuals. Our findings evidence the spatial vision loss before the onset of POAG.

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疑似原发性开角型青光眼患者的对比敏感度受损。

目的：评估原发性开角型青光眼（POAG）疑似患者的空间对比敏感度（CS）：方法：使用 4 个周期/度的正弦光栅测量 CS。首先，评估 34 名疑似 POAG 患者的眼窝和周边 CS，并分别与 71 名和 28 名年龄匹配的健康人的眼窝和周边情况进行比较。其次，对 34 名与疑似 POAG 患者年龄匹配的早期 POAG 患者的眼窝 CS 进行评估。分析考虑了两个年龄段：评估了 CS 与临床参数之间的相关性。同时还分析了诊断的准确性：结果：老年疑似 POAG 患者的周边 CS（23.4 ± 16.1）低于对照组（39.1 ± 28.2）（p = 0.040）。与对照组（50 岁以下：213.5 ± 66.2；50 岁以上：138.6 ± 71.7）相比，疑似 POAG 患者的眼窝 CS 降低（50 岁以下：146.8 ± 63.3；p = 0.004；50 岁以上：110.5 ± 65.0；p = 0.044），早期 POAG 患者的眼窝 CS 降低（50 岁以下：141.2 ± 72.6；p = 0.002；50 岁以上：80.2 ± 54.5；p < 0.001）。早期 POAG 患者的 CS 低于老年疑似 POAG 患者（p = 0.042）。眼窝 CS 与年龄相关（早期：p = 0.001；疑似：p = 0.002），仅在早期 POAG 患者中与杯盘比相关（p < 0.001）。眼窝 CS 对早期 POAG 患者的诊断准确性一般（AUC = 0.74）：结论：疑似 POAG 患者的 CS 值低于健康人。我们的研究结果证明，空间视力损失发生在 POAG 发病之前。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Sciences Neuroscience-General Neuroscience

CiteScore

4.80

自引率

9.10%

发文量

1472

审稿时长

18.71 days

期刊介绍： Brain Sciences (ISSN 2076-3425) is a peer-reviewed scientific journal that publishes original articles, critical reviews, research notes and short communications in the areas of cognitive neuroscience, developmental neuroscience, molecular and cellular neuroscience, neural engineering, neuroimaging, neurolinguistics, neuropathy, systems neuroscience, and theoretical and computational neuroscience. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Electronic files or software regarding the full details of the calculation and experimental procedure, if unable to be published in a normal way, can be deposited as supplementary material.