Unveiling phytochemical diversity and safety profile of hot water extract from Tetrapleura tetraptera fruit.

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-23 DOI:10.1186/s12906-024-04681-1

Chukwuma Raphael Ekeanyanwu, Chinelo Chinenye Nkwocha, Chidinma Lynda Ekeanyanwu

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Abstract

Background: Tetrapleura tetraptera, a widely used medicinal plant in West Africa, has been traditionally employed for various ailments. Despite its folkloric significance, scientific validation of its safety and potential neuroactive properties remains limited.

Objectives: This study aimed to investigate the acute and subchronic toxicity of Tetrapleura tetraptera hot water extract (HWETTF) in rats and to elucidate its phytochemical composition.

Methods: Acute oral toxicity was assessed in mice using the OECD guideline 423, while a 14-day repeat-dose toxicity study was conducted in rats. The phytochemical analysis included HPLC, FT-IR, and GC-MS.

Results: HWETTF exhibited no significant toxicity in acute or subchronic studies, even at high doses. Phytochemical analysis revealed a diverse array of compounds, including those with potential GABAergic and CNS depressant activities.

Conclusion: Tetrapleura tetraptera demonstrated a favourable safety profile in rodents and possesses a rich phytochemical composition. Further research is warranted to explore its potential neuroactive properties and develop therapeutic applications.

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揭示四叶草果实热水提取物的植物化学多样性和安全性特征

背景：四裂叶是西非一种广泛使用的药用植物，传统上被用于治疗各种疾病。尽管它在民间具有重要意义，但对其安全性和潜在神经活性特性的科学验证仍然有限：本研究旨在调查四叶草热水提取物（HWETTF）对大鼠的急性和亚慢性毒性，并阐明其植物化学成分：方法：根据 OECD 准则 423 评估了小鼠的急性口服毒性，并对大鼠进行了为期 14 天的重复剂量毒性研究。植物化学分析包括 HPLC、FT-IR 和 GC-MS：结果：HWETTF 在急性和亚慢性研究中均未显示出明显的毒性，即使在高剂量下也是如此。植物化学分析显示了多种化合物，包括具有潜在 GABA 能和中枢神经系统抑制活性的化合物：结论：四叶草在啮齿类动物中表现出良好的安全性，并具有丰富的植物化学成分。我们有必要开展进一步研究，探索其潜在的神经活性特性，并开发其治疗应用。

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