Association of childhood obesity or weight change with early-onset follicular occlusion triad among children.

IF 11 1区 医学 Q1 DERMATOLOGY British Journal of Dermatology Pub Date : 2024-10-22 DOI:10.1093/bjd/ljae414
Seong Rae Kim, Seong-Joon Koh, Hyunsun Park
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Abstract

Background: The effects of childhood obesity or weight gain on the development of early-onset follicular occlusion triad (FOT) among children, which includes hidradenitis suppurativa (HS), acne conglobata (AC), and dissecting cellulitis of the scalp (DCS), remain unknown.

Objectives: To investigate the association between body mass index (BMI) or its changes and early-onset FOT development.

Methods: This nationwide population-based longitudinal cohort study included a cohort of 2,012,928 Korean children who underwent two consecutive health examinations at 30-36 months and 42-48 months of age between 2009 and 2020. The BMI and its changes derived during health screenings at 30-36 and 42-48 months. We performed multivariate Cox proportional hazards regression analyses to estimate the risk of early-onset FOT, including HS, AC, and DCS.

Results: During the follow-up, 1,283 FOT, including 143 HS, 1,068 AC, and 72 DCS, events were identified. Children with obesity were at an elevated risk of early-onset FOT compared to those with a normal weight (FOT: adjusted hazard ratio [aHR] 1.49, 95% confidence interval [CI] 1.21-1.84; HS: aHR 2.30, 95% CI 1.39-3.82; AC: aHR 1.36, 95% CI 1.07-1.73). BMI gain was correlated with an elevated risk of early-onset FOT, particularly HS, whereas BMI loss was linked to a decreased risk of early-onset FOT, especially HS. Children who became obese had an increased early-onset FOT risk (aHR 1.51, 95% CI 1.07-2.14) compared to those who maintained a normal weight. Children who reduced from obese to normal weight exhibited a decreased risk of early-onset FOT (FOT: aHR 0.41, 95% CI 0.17-0.96, P for trend=0.02; HS: P for trend=0.05) compared to obese children who retained their weight.

Conclusions: Childhood obesity was associated with an elevated risk of early-onset FOT, including HS and AC. Weight gain was correlated with an increased risk of early-onset FOT, especially HS, while weight loss was associated with a decreased risk of early-onset FOT, particularly HS. Implementing purposeful weight-reduction strategies may be helpful in preventing early-onset FOT development.

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儿童肥胖或体重变化与早发性毛囊闭塞三联征的关系。
背景:儿童肥胖或体重增加对儿童早发性毛囊闭塞三联征(FOT)(包括化脓性扁平苔藓(HS)、充血性痤疮(AC)和头皮剥脱性蜂窝织炎(DCS))发病的影响尚不清楚:调查体重指数(BMI)或其变化与早发 FOT 发病之间的关系:这项以全国人口为基础的纵向队列研究包括 2,012,928 名韩国儿童,他们在 2009 年至 2020 年期间分别在 30-36 个月和 42-48 个月大时接受了两次连续的健康检查。在 30-36 个月和 42-48 个月的健康检查中得出的体重指数及其变化。我们进行了多变量考克斯比例危险回归分析,以估算包括HS、AC和DCS在内的早发FOT的风险:结果:在随访期间,共发现 1,283 例 FOT,包括 143 例 HS、1,068 例 AC 和 72 例 DCS。与体重正常的儿童相比,肥胖儿童罹患早发性FOT的风险更高(FOT:调整后危险比[aHR]1.49,95%置信区间[CI]1.21-1.84;HS:aHR 2.30,95%置信区间[CI]1.39-3.82;AC:aHR 1.36,95%置信区间[CI]1.07-1.73)。体重指数升高与早发FOT(尤其是HS)的风险升高有关,而体重指数降低则与早发FOT(尤其是HS)的风险降低有关。与体重保持正常的儿童相比,肥胖儿童的早发FOT风险增加(aHR 1.51,95% CI 1.07-2.14)。与体重保持正常的肥胖儿童相比,体重从肥胖降至正常的儿童早发FOT的风险降低(FOT:aHR 0.41,95% CI 0.17-0.96,趋势P=0.02;HS:趋势P=0.05):结论:儿童肥胖与早发 FOT(包括 HS 和 AC)的风险升高有关。实施有目的的减重策略可能有助于预防早期FOT的发生。
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来源期刊
British Journal of Dermatology
British Journal of Dermatology 医学-皮肤病学
CiteScore
16.30
自引率
3.90%
发文量
1062
审稿时长
2-4 weeks
期刊介绍: The British Journal of Dermatology (BJD) is committed to publishing the highest quality dermatological research. Through its publications, the journal seeks to advance the understanding, management, and treatment of skin diseases, ultimately aiming to improve patient outcomes.
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