A Case of Epithelioid Angiosarcoma Diagnosed From Gross Examination of a Pulmonary Tumor Utilizing Imprint Cytology and Immunocytochemistry

IF 1.5 Q4 ONCOLOGY Cancer reports Pub Date : 2024-10-23 DOI:10.1002/cnr2.70014

Tatsuya Mori, Keishi Mizuguchi, Chie Shimaguchi, Kaori Sakano, Tsubasa Shimoda, Urara Okawa, Miyu Okuda, Mayo Usui, Hiroko Ikeda

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Abstract

Background

Angiosarcoma, a very rare malignant tumor constituting 2%–4% of soft tissue sarcomas, manifest in diverse organs including skin, soft tissues, and bones. Histologically, angiosarcoma presents a wide range of morphologies, with epithelioid angiosarcoma (EAS) resemblance to carcinoma. The difficulty arises from the shared epithelial-like morphology and expression of epithelial markers in immunohistochemistry.

Case

This study reports a case where EAS diagnosis was achieved through a combination of gross findings in a lung resection sample, imprint cytology, and immunocytochemistry. Imprint cytology revealed clusters of epithelioid cells, while immunocytochemistry showed positive results for CD31, ERG, Fli-1, and AE1/AE3, proving instrumental in diagnosing EAS. The described immunocytochemical protocol facilitates prompt diagnosis exclusively through cytology samples.

Conclusion

This report emphasizes the potential for diagnosing EAS using cytological specimens, which is especially useful in cases where obtaining tissue samples proves challenging.

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一例利用印迹细胞学和免疫细胞化学从肺部肿瘤的大体检查中诊断出的上皮样血管肉瘤

背景：血管肉瘤是一种非常罕见的恶性肿瘤，占软组织肉瘤的 2%-4%，表现为皮肤、软组织和骨骼等多种器官。组织学上，血管肉瘤的形态多种多样，其中上皮样血管肉瘤（EAS）与癌相似。病例：本研究报告了一例通过肺部切除样本的大体检查结果、印迹细胞学和免疫细胞化学相结合确诊为上皮样血管肉瘤的病例。印迹细胞学显示有成群的上皮样细胞，而免疫细胞化学则显示 CD31、ERG、Fli-1 和 AE1/AE3 阳性，这有助于诊断 EAS。所述免疫细胞化学方案有助于仅通过细胞学样本进行及时诊断：本报告强调了利用细胞学标本诊断 EAS 的可能性，这在获取组织样本具有挑战性的病例中尤其有用。

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