Yan Shu, Shu Yao, Yan Luo, Hua-Juan Yang, Jia-Peng Wang, Le Cai
{"title":"A New Diterpenoid Alkaloid with Antimicrobial Activity from Aconitum brachypodum Diels","authors":"Yan Shu, Shu Yao, Yan Luo, Hua-Juan Yang, Jia-Peng Wang, Le Cai","doi":"10.1002/cbdv.202402400","DOIUrl":null,"url":null,"abstract":"<p>A new C<sub>20</sub>-denudatine-type diterpenoid alkaloid (DA) 11<i>S</i>-aconicarnine D (<b>1</b>) and fifteen known DAs were isolated from the lateral roots of <i>Aconitum brachypodum</i> Diels. Their structures were identified on the basis of extensive spectroscopic analyses, NMR calculations and DP4+ analysis. Compounds <b>1</b> and <b>4</b> exhibited antimicrobial activity against <i>Alternaria panax</i> with MICs of 2.00 and 8.00 μg/mL (Nystatin, 1.00 μg/mL), respectively.</p>","PeriodicalId":9878,"journal":{"name":"Chemistry & Biodiversity","volume":"22 3","pages":""},"PeriodicalIF":2.5000,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemistry & Biodiversity","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cbdv.202402400","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
A new C20-denudatine-type diterpenoid alkaloid (DA) 11S-aconicarnine D (1) and fifteen known DAs were isolated from the lateral roots of Aconitum brachypodum Diels. Their structures were identified on the basis of extensive spectroscopic analyses, NMR calculations and DP4+ analysis. Compounds 1 and 4 exhibited antimicrobial activity against Alternaria panax with MICs of 2.00 and 8.00 μg/mL (Nystatin, 1.00 μg/mL), respectively.
期刊介绍：
Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level.
Since 2017, Chemistry & Biodiversity is published in an online-only format.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
