SYNTHESIS, IN-SILICO BIOCHEMICAL PROPERTIES, AND IN-VITRO ANTIMICROBIAL ACTIVITY OF SOME FARMAZANS DERIVATIVES CONTAINING SULFONAMIDE MOIETY.

IF 2.3 3区 化学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Chemistry & Biodiversity Pub Date : 2024-10-24 DOI:10.1002/cbdv.202402488
Mohammad Asif, Mazen Almehmadi, Mamdouh Allahyani, Meshari A Alsuwat
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Abstract

The low effectiveness of currently available antibiotics is driving efforts worldwide to create new antimicrobial medicines. We made several novel formazan chemicals, including sulfonamides, and assessed how well they may work against bacteria. Consequently, attempts were undertaken to combine the moieties of formazan and sulfonamide to produce new derivatives or more effective antibacterial drugs. Condensing sulphanilamide with benzaldehydes in the presence of glacial acetic acid and ethanol produced a Schiff base of sulphonamide, which when combined with substituted benzene diazonium chlorides (2a-g) during condensation yields formazan derivatives (3a-g). Based on analytical and spectral data (IR, 1HNMR, and mass), the structures of all the synthesized compounds were described, and they agree well with the suggested ones. Using Ciprofloxacin and Ketoconazole as reference medications, the Agar diffusion method was utilized to assess the antibacterial activity of the synthesized compounds by measuring the zone of inhibition against harmful strains of bacteria and fungi. In contrast to the norm, every molecule examined has demonstrated a notable level of antibacterial activity.

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一些含磺酰胺分子的法马赞衍生物的合成、体内生化性质和体外抗菌活性。
现有抗生素疗效不佳,促使全世界都在努力开发新的抗菌药物。我们制造了几种新型的蚁酸化学物质,包括磺酰胺,并评估了它们对细菌的作用。因此,我们尝试将甲臢和磺酰胺的分子结合起来,生产出新的衍生物或更有效的抗菌药物。磺胺与苯甲醛在冰醋酸和乙醇存在下缩合,产生磺酰胺的希夫碱,在缩合过程中与取代的苯重氮氯化物(2a-g)结合,产生甲臢衍生物(3a-g)。根据分析和光谱数据(红外光谱、1HNMR 和质量),描述了所有合成化合物的结构,这些结构与建议的结构非常吻合。以环丙沙星和酮康唑为参照药物,采用琼脂扩散法测量合成化合物对有害细菌和真菌菌株的抑制区,以评估其抗菌活性。与常规方法不同的是,所研究的每个分子都表现出了显著的抗菌活性。
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来源期刊
Chemistry & Biodiversity
Chemistry & Biodiversity 环境科学-化学综合
CiteScore
3.40
自引率
10.30%
发文量
475
审稿时长
2.6 months
期刊介绍: Chemistry & Biodiversity serves as a high-quality publishing forum covering a wide range of biorelevant topics for a truly international audience. This journal publishes both field-specific and interdisciplinary contributions on all aspects of biologically relevant chemistry research in the form of full-length original papers, short communications, invited reviews, and commentaries. It covers all research fields straddling the border between the chemical and biological sciences, with the ultimate goal of broadening our understanding of how nature works at a molecular level. Since 2017, Chemistry & Biodiversity is published in an online-only format.
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