A Systematic Review of Stem Cell Applications in Maxillofacial Regeneration.

IF 2.5 Q2 DENTISTRY, ORAL SURGERY & MEDICINE Dentistry Journal Pub Date : 2024-09-29 DOI:10.3390/dj12100315
Man Hung, Mahsa Sadri, Melanie Katz, Connor Schwartz, Amir Mohajeri
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Abstract

Introduction: Regenerative medicine is revolutionizing oral and maxillofacial surgeries with stem cells, particularly mesenchymal stem cells, for tissue and bone regeneration. Despite promising in-vitro results, human trials are limited. A systematic review is needed to evaluate stem cell efficacy in maxillofacial issues, aiming to improve surgical outcomes and patient satisfaction.

Methods: Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines, this review included peer-reviewed articles (2013-2023) on stem cells in oral surgery, excluding non-English publications, abstracts, reviews, and opinion pieces. Searches were conducted in PubMed, Web of Science, OVID, Cochrane, Dentistry & Oral Sciences Source-Ebscohost, and Scopus. Two authors independently screened titles and abstracts, resolving disagreements by consensus. Full-text analysis involved extracting key data, verified by a secondary reviewer and additional quality checks.

Results: From 3540 initial articles, 2528 were screened after removing duplicates, and 7 met the inclusion criteria after excluding irrelevant studies. Key themes included the safety and efficacy of stem cell therapy, and bone regeneration and quality. Studies predominantly used mesenchymal stem cells. Findings showed positive outcomes in clinical safety and effectiveness and significant potential for bone regeneration.

Conclusions: This systematic review highlights the potential of stem cell therapies in maxillofacial applications, supporting their safety, efficacy, and bone regeneration capabilities. Further research is needed to standardize protocols and confirm long-term benefits.

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干细胞在颌面部再生中应用的系统回顾。
导言:再生医学利用干细胞,特别是间充质干细胞促进组织和骨骼再生,正在彻底改变口腔颌面外科手术。尽管体外试验结果令人鼓舞,但人体试验却十分有限。有必要进行系统回顾,评估干细胞在颌面问题上的疗效,以提高手术效果和患者满意度:根据《系统综述和元分析首选报告项目》(Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines),本综述纳入了关于口腔外科干细胞的同行评议文章(2013-2023年),排除了非英文出版物、摘要、综述和观点文章。在PubMed、Web of Science、OVID、Cochrane、Dentistry & Oral Sciences Source-Ebscohost和Scopus上进行了检索。两位作者分别独立筛选标题和摘要,并在协商一致的基础上解决分歧。全文分析包括提取关键数据,并由一名二级审稿人进行核实和额外的质量检查:从 3540 篇初始文章中,去除重复文章后筛选出 2528 篇,排除无关研究后有 7 篇符合纳入标准。关键主题包括干细胞疗法的安全性和有效性,以及骨再生和质量。研究主要使用间充质干细胞。研究结果显示,干细胞治疗在临床安全性和有效性方面取得了积极成果,在骨再生方面具有显著潜力:本系统综述强调了干细胞疗法在颌面部应用中的潜力,支持其安全性、有效性和骨再生能力。还需要进一步研究,以规范治疗方案,确认长期疗效。
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来源期刊
Dentistry Journal
Dentistry Journal Dentistry-Dentistry (all)
CiteScore
3.70
自引率
7.70%
发文量
213
审稿时长
11 weeks
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