Task-Based Eating and Drinking Interventions in Animal Models: A Narrative Review of Functional Improvements and Neuromuscular Adaptations in Age-Related Dysphagia.

IF 2.1 Q3 GERIATRICS & GERONTOLOGY Geriatrics Pub Date : 2024-10-22 DOI:10.3390/geriatrics9060138
Tina Hansen, Sabina Mette Staal, Nete Deela Rauhe Harreby, Ulla Andersen, Masumi Takeuchi Holm, Cecillie von Bülow, Eva Ejlersen Wæhrens
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Abstract

Background/objectives: Age-related dysphagia involves sarcopenia and nervous system changes affecting ingestion. The ACT-ING program, a novel task-based occupational therapy intervention, has been developed to improve strength, endurance, and ingestive skills using real-world eating and drinking tasks for older adults with age-related dysphagia. This narrative review evaluates the outcomes and neuromuscular adaptations of task-based eating and drinking interventions in aging animal models to inform potential refinements of the ACT-ING program and interpret results from an ongoing proof-of-concept study.

Methods: Publications were obtained from PubMed, SCOPUS, CINAHL, and EMBASE, and selected following the PRISMA guideline. Thirteen randomized trials investigated a task-based fluid-licking intervention in rats, combining strength, endurance, and skill training.

Results: Results suggested benefits in improving muscle strength, endurance, and swallowing skills in terms of quantity and speed. Although neuromuscular adaptations were less conclusive, the intervention appeared to induce cortical plasticity and increase fatigue-resistant muscle fibers in the involved muscles.

Conclusions: While these findings are promising, methodological concerns and potential biases were identified. Therefore, further research is necessary to refine the ACT-ING program, including both clinical studies in humans and preclinical studies in aging animal models that clearly define interventions targeting all aspects of ingestion-related skills within a motor learning and strength training framework.

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动物模型中基于任务的饮食干预:对老年性吞咽困难的功能改善和神经肌肉适应性的叙述性回顾。
背景/目的:与年龄相关的吞咽困难包括肌肉疏松症和影响摄食的神经系统变化。ACT-ING 计划是一项新颖的基于任务的职业疗法干预措施,它的开发目的是利用真实世界中的饮食任务来提高患有老年性吞咽困难的老年人的力量、耐力和摄食技能。这篇叙述性综述评估了基于任务的饮食干预在老年动物模型中的结果和神经肌肉适应性,为 ACT-ING 计划的潜在改进提供信息,并解释正在进行的概念验证研究的结果:从 PubMed、SCOPUS、CINAHL 和 EMBASE 中获取文献,并按照 PRISMA 指南进行筛选。13项随机试验调查了基于任务的大鼠舔液干预,将力量、耐力和技能训练相结合:结果:试验结果表明,在提高肌肉力量、耐力以及吞咽技能的数量和速度方面都有益处。虽然神经肌肉适应性的结论不太明确,但干预似乎诱导了大脑皮层的可塑性,并增加了相关肌肉中的抗疲劳肌纤维:虽然这些研究结果很有希望,但也发现了方法上的问题和潜在的偏差。因此,有必要开展进一步的研究来完善 ACT-ING 计划,包括人体临床研究和老龄化动物模型临床前研究,以在运动学习和力量训练框架内明确界定针对摄食相关技能各个方面的干预措施。
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来源期刊
Geriatrics
Geriatrics 医学-老年医学
CiteScore
3.30
自引率
0.00%
发文量
115
审稿时长
20.03 days
期刊介绍: • Geriatric biology • Geriatric health services research • Geriatric medicine research • Geriatric neurology, stroke, cognition and oncology • Geriatric surgery • Geriatric physical functioning, physical health and activity • Geriatric psychiatry and psychology • Geriatric nutrition • Geriatric epidemiology • Geriatric rehabilitation
期刊最新文献
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