Nathalia Lopez Duarte, Ana Paula Silva Bueno, Bárbara Sarni Sanches, Gabriella Alves Ramos, Layanara Albino Batista, Thalita Fernandes de Abreu, Marcelo Gerardin Poirot Land, Cristiane Bedran Milito
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引用次数: 0
Abstract
Malignant lymphoma is an unusual form of gallbladder neoplasm. Almost all these tumors are diffuse large B-cell lymphomas or mucosa-associated lymphoid tissue-type lymphomas. Herein, we present a literature review of gallbladder Burkitt's lymphoma (BL) cases that includes also an unpublished case in an HIV-infected child, observed by our center. The patient (a five-year-old black female child) attended the Federal Hospital of Lagoa, Rio de Janeiro, Brazil, underwent cholecystectomy, and the postoperative pathological analysis of the gallbladder revealed a diagnosis of BL (EBV-positive). Also, HIV serology was performed and returned positive. She was transferred to the Martagão Gesteira Institute of Pediatrics and Childcare for oncological treatment, dying from sepsis and disease progression about 18 months later. The patient did not undergo ART/cART. Previous cases of gallbladder BL were herein described and analyzed to characterize the clinicopathological features and possible similarities. BL can occur in the gallbladder both in the context of HIV infection and in the pediatric population. A biopsy is mandatory in cases with suggestive findings of lymphoma, and an early diagnosis can change the course of the disease. Furthermore, the case highlights the importance of an early initiation of ART/cART in people living with HIV (PLWH), especially in children.
恶性淋巴瘤是一种不常见的胆囊肿瘤。这些肿瘤几乎都是弥漫大B细胞淋巴瘤或粘膜相关淋巴组织型淋巴瘤。在此,我们对胆囊伯基特淋巴瘤(BL)病例进行了文献综述,其中还包括本中心观察到的一例未发表的 HIV 感染儿童病例。患者(一名五岁的黑人女性儿童)在巴西里约热内卢的拉戈阿联邦医院接受了胆囊切除术,术后胆囊病理分析显示诊断为BL(EBV阳性)。此外,还进行了艾滋病毒血清学检查,结果呈阳性。她被转到马尔塔甘-盖斯提拉儿科和儿童保健研究所(Martagão Gesteira Institute of Pediatrics and Childcare)接受肿瘤治疗,约18个月后死于败血症和疾病进展。患者没有接受抗逆转录病毒疗法/卡介苗治疗。本文对以往的胆囊癌病例进行了描述和分析,以确定其临床病理特征和可能的相似之处。胆囊炎既可发生在艾滋病病毒感染者中,也可发生在儿童人群中。对于提示淋巴瘤的病例,必须进行活检,早期诊断可改变病程。此外,该病例还强调了对艾滋病病毒感染者(PLWH),尤其是儿童及早开始抗逆转录病毒疗法(ART)/抗逆转录病毒疗法(cART)的重要性。