Single Nucleotide Polymorphisms and Tendon/Ligament Injuries in Athletes: A Systematic Review and Meta-analysis.

IF 2 4区 医学 Q2 SPORT SCIENCES International journal of sports medicine Pub Date : 2025-01-01 Epub Date: 2024-10-22 DOI:10.1055/a-2419-4359
Yumi Fukuyama, Haruka Murakami, Motoyuki Iemitsu
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Abstract

This systematic review and meta-analysis aimed to identify the association between genetic polymorphisms and tendon and ligament injuries in adolescent and adult athletes of multiple competition sports. The PubMed, Web of Science, EBSCO, Cochrane Library, and MEDLINE databases were searched until July 7, 2023. Eligible articles included genetic studies on tendon and ligament injuries and comparisons between injured and non-injured athletes. This review included 31 articles, comprising 1,687 injury cases and 2,227 controls, from a meta-analysis of 12 articles. We identified 144 candidate gene polymorphisms (only single nucleotide polymorphisms were identified). The meta-analyses included vascular endothelial growth factor A (VEGFA) rs699947, collagen type I alpha 1 rs1800012, collagen type V alpha 1 rs12722, and matrix metalloproteinase 3 rs679620. The VEGFA rs699947 polymorphism showed a lower risk of injuries in athletes with the C allele ([C vs. A]: OR=0.80, 95% CI: 0.65-0.98, I 2 =3.82%, p=0.03). The risk of these injuries were not affected by other polymorphisms. In conclusion, the VEGFA rs699947 polymorphism is associated with the risk of tendon and ligament injuries in athletes. This study provides insights into genetic variations that contribute to our understanding of the risk factors for such injuries in athletes.

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单核苷酸多态性与运动员肌腱/韧带损伤:系统回顾与元分析》。
本系统综述和荟萃分析旨在确定多种竞技运动的青少年和成年运动员的基因多态性与肌腱和韧带损伤之间的关联。对 PubMed、Web of Science、EBSCO、Cochrane Library 和 MEDLINE 数据库的检索截止到 2023 年 7 月 7 日。符合条件的文章包括有关肌腱和韧带损伤的遗传学研究,以及受伤运动员和未受伤运动员之间的比较。本综述从对 12 篇文章的荟萃分析中选取了 31 篇文章,其中包括 1,687 例损伤病例和 2,227 例对照病例。我们确定了 144 个候选基因多态性(仅确定了单核苷酸多态性)。荟萃分析包括血管内皮生长因子 A(VEGFA)rs699947、胶原 I 型 alpha 1 rs1800012、胶原 V 型 alpha 1 rs12722 和基质金属蛋白酶 3 rs679620。VEGFA rs699947 多态性显示,C 等位基因的运动员受伤风险较低([C vs. A]:OR=0.80,95% CI:0.65-0.98,I 2 =3.82%,p=0.03)。这些损伤的风险不受其他多态性的影响。总之,VEGFA rs699947 多态性与运动员肌腱和韧带损伤的风险有关。这项研究提供了对遗传变异的见解,有助于我们了解运动员发生此类损伤的风险因素。
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来源期刊
CiteScore
4.80
自引率
4.00%
发文量
111
审稿时长
3-8 weeks
期刊介绍: The IJSM provides a forum for the publication of papers dealing with both basic and applied information that advance the field of sports medicine and exercise science, and offer a better understanding of biomedicine. The journal publishes original papers, reviews, short communications, and letters to the Editors.
期刊最新文献
Epidemiology of fractures and care in male collegiate Taekwondo athletes by weight classes. Modeling the marathon and human endurance performance: Some thoughts and what's new? Optimizing recovery: the impact of training load in elite volleyball players. Effects of blood flow restriction training in athletes: a systematic review meta-analysis. Evaluating optimal height for hamstring activity in maximum-speed single-leg bridge test.
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