The role of non-coding RNAs in fibroblast-like synoviocytes in rheumatoid arthritis

IF 2.4 4区 医学 Q2 RHEUMATOLOGY International Journal of Rheumatic Diseases Pub Date : 2024-10-23 DOI:10.1111/1756-185X.15376
Yongquan Zheng, Xiaoyu Cai, Fujia Ren, Yao Yao
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Abstract

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by synovial hyperplasia, and fibroblast-like synoviocytes (FLSs) constitute the majority of cells in the synovial tissue, playing a crucial role in the onset of RA. Dysregulation of FLSs function is a critical strategy in treating joint damage associated with RA. Non-coding RNAs, a class of RNA molecules that do not encode proteins, participate in the development of various diseases. This article aims to review the progress in the study of long non-coding RNAs, microRNAs, and circular RNAs in FLSs. Non-coding RNAs are involved in the pathogenesis of RA, directly or indirectly regulating FLSs' proliferation, migration, invasion, apoptosis, and inflammatory responses. Furthermore, non-coding RNAs also influence DNA methylation and osteogenic differentiation in FLSs. Therefore, non-coding RNAs hold promise as biomarkers for diagnosing RA. Targeting non-coding RNAs in FLSs locally represents a potential strategy for future therapies in RA.

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非编码 RNA 在类风湿性关节炎成纤维细胞样滑膜细胞中的作用。
类风湿性关节炎(RA)是一种以滑膜增生为特征的炎症性自身免疫性疾病,成纤维细胞样滑膜细胞(FLSs)是滑膜组织中的主要细胞,在 RA 的发病中起着至关重要的作用。调控FLSs的功能是治疗与RA相关的关节损伤的关键策略。非编码 RNA 是一类不编码蛋白质的 RNA 分子,它参与了多种疾病的发展。本文旨在回顾长非编码 RNA、microRNA 和环状 RNA 在 FLSs 中的研究进展。非编码 RNA 参与了 RA 的发病机制,直接或间接调控 FLSs 的增殖、迁移、侵袭、凋亡和炎症反应。此外,非编码 RNA 还会影响 FLSs 的 DNA 甲基化和成骨分化。因此,非编码 RNA 有希望成为诊断 RA 的生物标记物。局部靶向 FLSs 中的非编码 RNA 是未来治疗 RA 的一种潜在策略。
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来源期刊
CiteScore
3.70
自引率
4.00%
发文量
362
审稿时长
1 months
期刊介绍: The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.
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