Prevalence of Lipoprotein(a) Measurement and its Association with Arteriosclerosis in Asymptomatic Individuals in China.

IF 3 2区 医学 Q2 PERIPHERAL VASCULAR DISEASE Journal of atherosclerosis and thrombosis Pub Date : 2024-10-22 DOI:10.5551/jat.65214
Ping-Ting Yang, Li Tang, Hui-Rong Guo, Yong-Mei He, Yue-Xiang Qin, Lei Yan, Zhen-Xin Li, Ya-Zhang Guo, Jian-Gang Wang
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Abstract

Aims: Lipoprotein(a) [Lp(a)] is an independent risk factor for atherosclerotic cardiovascular disease (ASCVD), and its level is genetically determined. Although guidelines and consensuses in various cardiovascular fields have emphasized the importance of Lp(a), screening for Lp(a) in China has not been well studied.

Methods: A cross-sectional study was conducted using a random sample of 30,000 medical examiners from each of the five health check-up centres. The distribution of Lp(a) was described for those who completed Lp(a) testing, and logistic regression modelling was used to evaluate the relationship between Lp(a) levels and vascular structure and function in the population who underwent carotid ultrasound and brachial‒ankle pulse wave velocity (baPWV) measurements.

Results: Lp(a) was measured in only 4400 (3.02%) of the 150,000 participants. Among those tested for Lp(a), the median concentration was 15.85 mg/dL. The proportion of participants with Lp(a) levels ≥ 30 mg/dL was 15.00%. Multiple logistic regression analysis revealed a significant correlation between Lp(a) and cIMT ≥ 1.0 mm (OR: 1.008, 95% CI: 1.001-1.014, P=0.020) and carotid artery plaques (OR: 1.010, 95% CI: 1.004-1.016, P=0.001) but no correlation with baPWV ≥ 1400 (OR: 0.999, 95% CI: 0.993-1.005, P=0.788) or baPWV ≥ 1800 (OR: 1.002, 95% CI: 0.993-1.011, P=0.634).

Conclusions: The detection rate of Lp(a) at health checkups is low, and Lp(a) is positively associated with cervical vascular sclerosis and plaque but not with baPWV. Therefore, the testing rate of Lp(a) and the awareness of the risk of vascular structural changes due to Lp(a) should be further improved.

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中国无症状人群中脂蛋白(a)测量的普遍性及其与动脉硬化的关系。
目的:脂蛋白(a)[Lp(a)]是动脉粥样硬化性心血管疾病(ASCVD)的独立危险因素,其水平由基因决定。尽管各种心血管领域的指南和共识都强调了脂蛋白(a)的重要性,但在中国对脂蛋白(a)筛查的研究并不多:方法:我们从五个健康体检中心随机抽取了 30,000 名体检者,进行了一项横断面研究。结果:在接受颈动脉超声和肱踝脉搏波速度(baPWV)测量的人群中,脂蛋白(a)水平与血管结构和功能之间的关系采用逻辑回归模型进行评估:在 15 万名参与者中,只有 4400 人(3.02%)检测到了脂蛋白(a)。在接受脂蛋白(a)检测的人中,中位浓度为 15.85 mg/dL。脂蛋白(a)水平≥30 毫克/分升的参与者比例为 15.00%。多元逻辑回归分析显示,脂蛋白(a)与 cIMT ≥ 1.0 mm(OR:1.008,95% CI:1.001-1.014,P=0.020)和颈动脉斑块(OR:1.010,95% CI:1.004-1.016,P=0.001),但与baPWV≥1400(OR:0.999,95% CI:0.993-1.005,P=0.788)或baPWV≥1800(OR:1.002,95% CI:0.993-1.011,P=0.634)无相关性:健康体检中脂蛋白(a)的检出率较低,脂蛋白(a)与宫颈血管硬化和斑块呈正相关,但与 baPWV 无关。因此,应进一步提高脂蛋白(a)的检测率和对脂蛋白(a)导致血管结构变化风险的认识。
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来源期刊
CiteScore
6.60
自引率
15.90%
发文量
271
审稿时长
1 months
期刊介绍: JAT publishes articles focused on all aspects of research on atherosclerosis, vascular biology, thrombosis, lipid and metabolism.
期刊最新文献
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