Efficacy of atorvastatin on renal function in patients with contrast-induced nephropathy after percutaneous coronary intervention.

IF 1.5 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Cardiothoracic Surgery Pub Date : 2024-10-24 DOI:10.1186/s13019-024-03052-8
Heng Li, Hongen Wang, Siqi Ren, Ruihong Zhou
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Abstract

Background: At present, the clinical methods for preventing and treating contrast-induced nephropathy (CIN) are limited, and statins can play a better role during this process. So, we aimed to assess the atorvastatin on renal function in nephropathy patients after percutaneous coronary intervention (PCI).

Methods: In this work, 100 elderly patients with coronary heart disease (CHD) were selected into an experimental group (Exp group, 50 cases, 40 mg/d po atorvastatin) and a control group (Ctrl group, 50 cases, 10 mg/d po atorvastatin). The renal function indicators, blood routine indicators, and the incidence of adverse reactions (ARs) were compared between patients in Exp and Ctrl groups.

Results: After surgery, the levels of serum creatinine (SCr), blood urea nitrogen (BUN), cystatin C (CysC), high-sensitivity C-reactive protein (hs-CRP), and interleukin (IL6) in patients in the Exp group were much lower, and the levels of estimated glomerular filtration rate (eGFR) and superoxide dismutase (SOD) were higher (all P < 0.05). Meanwhile, the incidences of ARs during hospitalization between patients in the Exp and Ctrl groups were all 8%, showing no observable difference (P > 0.05). Compared with conventional doses of atorvastatin, high-dose atorvastatin can effectively prevent renal function damage in patients with CIN, decrease the inflammation and oxidative stress in patients, and will not increase the risk of ARs during hospitalization.

Conclusion: Taken together, high-dose atorvastatin can be applied in treating patients with CHD after PCI due to its excellent efficacy and high safety.

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阿托伐他汀对经皮冠状动脉介入术后造影剂诱发肾病患者肾功能的疗效。
背景:目前,临床上预防和治疗造影剂诱发肾病(CIN)的方法有限,而他汀类药物可以在此过程中发挥更好的作用。因此,我们旨在评估阿托伐他汀对经皮冠状动脉介入治疗(PCI)后肾病患者肾功能的影响:方法:选取 100 例老年冠心病(CHD)患者,分为实验组(Exp 组,50 例,阿托伐他汀 40 mg/d)和对照组(Ctrl 组,50 例,阿托伐他汀 10 mg/d)。比较实验组和对照组患者的肾功能指标、血常规指标和不良反应(ARs)发生率:结果:术后,Exp 组患者的血清肌酐(SCr)、血尿素氮(BUN)、胱抑素 C(CysC)、高敏 C 反应蛋白(hs-CRP)和白细胞介素(IL6)水平明显降低,而估计肾小球滤过率(eGFR)和超氧化物歧化酶(SOD)水平较高(均为 P0.05)。与常规剂量阿托伐他汀相比,大剂量阿托伐他汀能有效预防CIN患者的肾功能损伤,降低患者的炎症反应和氧化应激反应,且不会增加住院期间发生ARs的风险:综上所述,大剂量阿托伐他汀具有良好的疗效和较高的安全性,可用于PCI术后冠心病患者的治疗。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Cardiothoracic Surgery
Journal of Cardiothoracic Surgery 医学-心血管系统
CiteScore
2.50
自引率
6.20%
发文量
286
审稿时长
4-8 weeks
期刊介绍: Journal of Cardiothoracic Surgery is an open access journal that encompasses all aspects of research in the field of Cardiology, and Cardiothoracic and Vascular Surgery. The journal publishes original scientific research documenting clinical and experimental advances in cardiac, vascular and thoracic surgery, and related fields. Topics of interest include surgical techniques, survival rates, surgical complications and their outcomes; along with basic sciences, pediatric conditions, transplantations and clinical trials. Journal of Cardiothoracic Surgery is of interest to cardiothoracic and vascular surgeons, cardiothoracic anaesthesiologists, cardiologists, chest physicians, and allied health professionals.
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