Core-Shell Microspheres with Encapsulated Gold Nanoparticle Carriers for Controlled Release of Anti-Cancer Drugs.

IF 5 3区 医学 Q1 ENGINEERING, BIOMEDICAL Journal of Functional Biomaterials Pub Date : 2024-09-24 DOI:10.3390/jfb15100277
Lin Guo, Qilong Zhao, Min Wang
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Abstract

Cancer is one of the major threats to human health and lives. However, effective cancer treatments remain a great challenge in clinical medicine. As a common approach for cancer treatment, chemotherapy has saved the life of millions of people; however, patients who have gone through chemotherapy often suffer from severe side effects owing to the inherent cytotoxicity of anti-cancer drugs. Stabilizing the blood concentration of an anti-cancer drug will reduce the occurrence or severity of side effects, and relies on using an appropriate drug delivery system (DDS) for achieving sustained or even on-demand drug delivery. However, this is still an unmet clinical challenge since the mainstay of anti-cancer drugs is small molecules, which tend to be diffused rapidly in the body, and conventional DDSs exhibit the burst release phenomenon. Here, we establish a class of DDSs based on biodegradable core-shell microspheres with encapsulated doxorubicin hydrochloride-loaded gold nanoparticles (DOX@Au@MSs), with the core-shell microspheres being made of poly(lactic-co-glycolic acid) in the current study. By harnessing the physical barrier of the biodegradable shell of core-shell microspheres, DOX@Au@MSs can provide a sustained release of the anti-cancer drug in the test duration (which is 21 days in the current study). Thanks to the photothermal properties of the encapsulated gold nanoparticle carriers, the core-shell biodegradable microspheres can be ruptured through remotely controlled near-infrared (NIR) light, thereby achieving an NIR-controlled triggered release of the anti-cancer drug. Furthermore, the route of the DOX-Au@MS-enabled controlled release of the anti-cancer drug can provide durable cancer cell ablation for the long period of 72 h.

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包裹金纳米粒子载体的核壳微球用于抗癌药物的控释。
癌症是人类健康和生命的主要威胁之一。然而,有效的癌症治疗仍然是临床医学面临的巨大挑战。作为治疗癌症的常用方法,化疗挽救了数百万人的生命;然而,由于抗癌药物固有的细胞毒性,接受化疗的患者往往会出现严重的副作用。稳定抗癌药物的血药浓度可以降低副作用的发生率或严重程度,这有赖于使用适当的给药系统(DDS)来实现持续甚至按需给药。然而,由于抗癌药物主要是小分子药物,在体内扩散速度快,而传统的给药系统会出现猝发释放现象,因此这仍是一个尚未解决的临床难题。在这里,我们建立了一类基于可生物降解的核壳微球的 DDSs,其中封装了盐酸多柔比星负载的金纳米粒子(DOX@Au@MSs)。通过利用核壳微球可生物降解外壳的物理屏障,DOX@Au@MSs 可在测试期间(本研究中为 21 天)持续释放抗癌药物。由于封装金纳米粒子载体的光热特性,核壳生物可降解微球可通过远程控制的近红外(NIR)光破裂,从而实现近红外控制的抗癌药物触发释放。此外,DOX-Au@MS 实现抗癌药物控释的途径可提供 72 小时的持久癌细胞消融。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Functional Biomaterials
Journal of Functional Biomaterials Engineering-Biomedical Engineering
CiteScore
4.60
自引率
4.20%
发文量
226
审稿时长
11 weeks
期刊介绍: Journal of Functional Biomaterials (JFB, ISSN 2079-4983) is an international and interdisciplinary scientific journal that publishes regular research papers (articles), reviews and short communications about applications of materials for biomedical use. JFB covers subjects from chemistry, pharmacy, biology, physics over to engineering. The journal focuses on the preparation, performance and use of functional biomaterials in biomedical devices and their behaviour in physiological environments. Our aim is to encourage scientists to publish their results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Several topical special issues will be published. Scope: adhesion, adsorption, biocompatibility, biohybrid materials, bio-inert materials, biomaterials, biomedical devices, biomimetic materials, bone repair, cardiovascular devices, ceramics, composite materials, dental implants, dental materials, drug delivery systems, functional biopolymers, glasses, hyper branched polymers, molecularly imprinted polymers (MIPs), nanomedicine, nanoparticles, nanotechnology, natural materials, self-assembly smart materials, stimuli responsive materials, surface modification, tissue devices, tissue engineering, tissue-derived materials, urological devices.
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