Comparison of Demographic and Clinical Characteristics of Taiwan Biobank Participants with Nonparticipants.

IF 3.7 2区 医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Journal of Epidemiology Pub Date : 2024-10-26 DOI:10.2188/jea.JE20240297
Chi-Shin Wu, Le-Yin Hsu, Chen-Yang Shen, Wei J Chen, Mei-Chen Lin, Chun Chieh Fan, Shi-Heng Wang
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Abstract

Background: This study investigated fundamental demographic variables within the Taiwan Biobank (TWBB) and compared them with national demographic statistics. Additionally, a matched cohort analysis compared TWBB participants with nonparticipants to uncover disparities in sociodemographic and clinical characteristics.

Methods: A total of 128,663 individuals aged 30 to 70 without cancer were recruited within the TWBB, and 514,652 nonparticipants matched by age and sex were randomly selected from the National Health Insurance claims database. Sociodemographic variables, healthcare utilization metrics, underlying medical conditions, and subsequent mortality and cancer risk were analyzed.

Results: TWBB participants were more likely to be female, older, married, higher educated, with higher incomes, and urban residency. Healthcare utilization metrics showed minimal differences. Pre-cohort entry, TWBB participants had a higher prevalence of certain medical conditions, such as peptic ulcer disease, osteoarthritis, osteoporosis, and uterine leiomyoma in females. During follow-up periods, elevated mortality rates were observed among TWBB participants but decreased cancer risk.

Conclusion: The TWBB cohort exhibits disparities in sociodemographic and health-related attributes compared to the general population, comprising older, females, married, higher educated, higher income, and predominantly in urban areas. While mortality rates are slightly elevated within the TWBB cohort, cancer incidence rates are lower. Despite limitations in representativeness, the TWBB's size and exposure measures offer valuable insights into associations between exposures and health conditions.

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台湾生物库参与者与非参与者的人口统计学和临床特征比较。
研究背景本研究调查了台湾生物样本库(TWBB)中的基本人口统计学变量,并将其与全国人口统计学数据进行了比较。此外,一项匹配队列分析比较了台湾生物库参与者和非参与者,以揭示社会人口和临床特征的差异:在 TWBB 中招募了 128,663 名年龄在 30 岁至 70 岁之间的非癌症患者,并从国民健康保险索赔数据库中随机抽取了 514,652 名年龄和性别匹配的非参与者。对社会人口学变量、医疗保健使用指标、基础医疗条件以及随后的死亡率和癌症风险进行了分析:结果:TWBB 参与者更可能是女性、老年人、已婚者、受过高等教育者、收入较高者和城市居民。医疗保健利用率指标显示差异很小。在加入队列前,TWBB 参与者的某些疾病患病率较高,如消化性溃疡、骨关节炎、骨质疏松症和女性子宫肌瘤。在随访期间,观察到 TWBB 参与者的死亡率升高,但癌症风险降低:与普通人群相比,TWBB 群体在社会人口学和健康相关属性方面存在差异,包括老年人、女性、已婚、受过高等教育、收入较高、主要居住在城市地区。虽然 TWBB 群体的死亡率略高,但癌症发病率较低。尽管 TWBB 在代表性方面存在局限性,但其规模和暴露测量方法为了解暴露与健康状况之间的关联提供了宝贵的信息。
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来源期刊
Journal of Epidemiology
Journal of Epidemiology 医学-公共卫生、环境卫生与职业卫生
CiteScore
7.50
自引率
4.30%
发文量
172
审稿时长
6-12 weeks
期刊介绍: The Journal of Epidemiology is the official open access scientific journal of the Japan Epidemiological Association. The Journal publishes a broad range of original research on epidemiology as it relates to human health, and aims to promote communication among those engaged in the field of epidemiological research and those who use epidemiological findings.
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