Circadian re-set repairs long-COVID in a prodromal Parkinson's parallel: a case series.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL Journal of Medical Case Reports Pub Date : 2024-10-23 DOI:10.1186/s13256-024-04812-9
Gregory L Willis, Takuyuki Endo, Saburo Sakoda
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Abstract

Background: In this case series, results from daily visual exposure to intense polychromatic light of 2000 to 4000 LUX is presented. Bright light treatment is a standard procedure for treating seasonal affective disorder and prodromal Parkinson's disease with high success. With the post-encephalitic symptoms of long-COVID closely approximating those of prodromal Parkinson's disease, we treated insomnia and sleep-related parameters in these patients, including total sleep, number of awakenings, tendency to fall back to sleep, and fatigue, to determine whether mending sleep could improve quality of life.

Case presentation: We present three female and two male Caucasian patients aged 42-70 years with long-COVID that persisted from 12 weeks to 139 weeks after contracting coronavirus disease.

Conclusion: A light presentation protocol was adapted for long-COVID that not only restored sleep in all patients, but also unexpectedly repaired the depression, anxiety, and cognitive changes (brain fog) as well. A robust pattern of recovery commencing 4-5 days after treatment and was maintained for weeks to months without relapse. These preliminary findings represent a novel, minimally invasive approach for managing the most debilitating symptoms of long-COVID, making it an ideal candidate for the drug hypersensitive, post-encephalitic brain. That a compromised circadian mechanism seen in Parkinson's disease may also underlie post-encephalitic long-COVID implicates a compromised role of the circadian system in these disorders.

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帕金森并发症前兆中的昼夜节律重设修复长COVID:一个病例系列。
背景:在本系列病例中,介绍了每天在 2000 至 4000 LUX 的多色强光下进行视觉照射的结果。强光治疗是治疗季节性情感障碍和帕金森病前驱症状的标准程序,成功率很高。由于长COVID的脑病后症状与帕金森病前驱症状十分相似,我们对这些患者的失眠和睡眠相关指标进行了治疗,包括总睡眠时间、觉醒次数、再次入睡倾向和疲劳程度,以确定改善睡眠是否能提高生活质量:我们介绍了三位女性和两位男性白种人患者,他们的年龄在 42-70 岁之间,在感染冠状病毒疾病后的 12 周至 139 周内持续出现长 COVID:结论:针对长期慢性阻塞性肺气肿采用了一种轻型演示方案,不仅恢复了所有患者的睡眠,还出乎意料地修复了抑郁、焦虑和认知变化(脑雾)。从治疗后 4-5 天开始,患者就出现了强劲的恢复模式,并可维持数周至数月之久而不再复发。这些初步研究结果代表了一种新颖的微创方法,可用于治疗长期慢性阻塞性脑损伤最令人衰弱的症状,是药物过敏性脑损伤后大脑的理想选择。帕金森病中的昼夜节律机制受损也可能是脑病后长期COVID的基础,这说明昼夜节律系统在这些疾病中的作用受到了损害。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of Medical Case Reports
Journal of Medical Case Reports Medicine-Medicine (all)
CiteScore
1.50
自引率
0.00%
发文量
436
期刊介绍: JMCR is an open access, peer-reviewed online journal that will consider any original case report that expands the field of general medical knowledge. Reports should show one of the following: 1. Unreported or unusual side effects or adverse interactions involving medications 2. Unexpected or unusual presentations of a disease 3. New associations or variations in disease processes 4. Presentations, diagnoses and/or management of new and emerging diseases 5. An unexpected association between diseases or symptoms 6. An unexpected event in the course of observing or treating a patient 7. Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
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