Parathyroid carcinoma: a tertiary centre's experience over 15 years.

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY Journal of Laryngology and Otology Pub Date : 2024-10-23 DOI:10.1017/S0022215124001476

Jeremy Wong, Alfred Addison, Ramez Nassif

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Abstract

Objectives: The aim of this research is to determine the rate of recurrence, metastasis and survival outcomes of patients diagnosed with and treated for parathyroid carcinoma.

Methods: This research is a retrospective chart review for patients diagnosed with parathyroid carcinomas between 1 January 2007 and 31 December 2022 in a UK tertiary centre.

Results: Fourteen patients were identified, all of whom received surgery following their diagnosis. On presentation, all patients (100 per cent) were hypercalcaemic, with two patients (14 per cent) having metastatic lesions. There was a single case (7 per cent) of loco-regional recurrence following surgery. Six patients passed away after a median follow up of 2.5 years, four due to causes related to parathyroid carcinoma.

Conclusion: Surgical excision remains the mainstay of treatment, but this can only be undertaken after the patient has been medically stabilised. Mortality in this group of patients generally arose from the effects of hypercalcaemia. Metastasis and recurrence from our cohort were rare, but long-term follow up with monitoring of calcium and parathyroid hormone levels remain keys.

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甲状旁腺癌 - 一家三级医疗中心 15 年来的经验。

目的：本研究的目的是确定诊断和治疗甲状旁腺癌患者的复发、转移率和生存结局。方法：本研究是对2007年1月1日至2022年12月31日在英国三级中心诊断为甲状旁腺癌的患者进行回顾性图表回顾。结果：14例患者均在确诊后接受手术治疗。在就诊时，所有患者（100%）均为高钙血症，其中2例患者（14%）有转移性病变。有一例（7%）手术后局部区域复发。6例患者在中位随访2.5年后去世，其中4例因与甲状旁腺癌相关的原因。结论：手术切除仍然是治疗的主要方法，但这只能在患者医学稳定后进行。这组患者的死亡率一般由高钙血症引起。在我们的队列中转移和复发是罕见的，但长期随访监测钙和甲状旁腺激素水平仍然是关键。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.