Asim Mushtaq, Muhammad Zubair Iqbal, Jianbin Tang, Wenjing Sun
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引用次数: 0
Abstract
Global mortality data indicates cancer as the second-leading cause of death worldwide. Therefore, there's a pressing need to innovate effective treatments to address this significant medical and societal challenge. In recent years, X-ray-induced photodynamic therapy (X-PDT) has emerged as a promising advancement, revolutionizing traditional photodynamic therapy (PDT) for deeply entrenched malignancies by harnessing penetrating X-rays as external stimuli. Recent developments in X-ray photodynamic therapy have shown a trend toward minimizing radiation doses to remarkably low levels after the proof-of-concept demonstration. Early detection and real-time monitoring are crucial aspects of effective cancer treatment. Sophisticated X-ray imaging techniques have been enhanced by the introduction of X-ray luminescence nano-agents, alongside contrast nanomaterials based on X-ray attenuation. X-ray luminescence-based in vivo imaging offers excellent detection sensitivity and superior image quality in deep tissues at a reasonable cost, due to unhindered penetration and unimpeded auto-fluorescence of X-rays. This review emphasizes the significance of X-ray responsive theranostics, exploring their mechanism of action, feasibility, biocompatibility, and promising prospects in imaging-guided therapy for deep-seated tumors. Additionally, it discusses promising applications of X-PDT in treating breast cancer, liver cancer, lung cancer, skin cancer, and colorectal cancer.
全球死亡率数据显示,癌症是全球第二大死因。因此,迫切需要创新有效的治疗方法来应对这一重大的医疗和社会挑战。近年来,X 射线诱导光动力疗法(X-PDT)已成为一种前景广阔的先进疗法,它利用穿透性 X 射线作为外部刺激,彻底改变了传统的光动力疗法(PDT),可用于治疗根深蒂固的恶性肿瘤。X 射线光动力疗法的最新进展表明,经过概念验证后,辐射剂量有明显降低的趋势。早期检测和实时监测是有效治疗癌症的关键环节。通过引入 X 射线发光纳米试剂以及基于 X 射线衰减的对比纳米材料,先进的 X 射线成像技术得到了增强。由于 X 射线的无阻碍穿透和无阻碍自发荧光,基于 X 射线发光的活体成像以合理的成本在深层组织中提供了出色的检测灵敏度和卓越的图像质量。这篇综述强调了 X 射线响应治疗技术的意义,探讨了其作用机制、可行性、生物相容性以及在成像引导下治疗深部肿瘤的前景。此外,它还讨论了 X-PDT 在治疗乳腺癌、肝癌、肺癌、皮肤癌和结直肠癌方面的应用前景。
期刊介绍:
Journal of Nanobiotechnology is an open access peer-reviewed journal communicating scientific and technological advances in the fields of medicine and biology, with an emphasis in their interface with nanoscale sciences. The journal provides biomedical scientists and the international biotechnology business community with the latest developments in the growing field of Nanobiotechnology.