Impact of limited language proficiency on participation in venous thromboembolism research: a retrospective analysis.

IF 5.5 2区 医学 Q1 HEMATOLOGY Journal of Thrombosis and Haemostasis Pub Date : 2024-10-21 DOI:10.1016/j.jtha.2024.09.014
Desmond Anuku, Marc Carrier, Grégoire Le Gal, Lana Castellucci, Philip Wells, Deborah Siegal, Tzu-Fei Wang, Lisa Duffett, Miriam Kimpton, Joseph Shaw, Tamara L Morgan, Jude-Mary Cénat, Aurélien Delluc, Yan Xu
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Abstract

Background: Limited language proficiency is an established barrier to research participation among racialized populations. While prior studies have highlighted the underrepresentation of racialized populations in venous thromboembolism (VTE) research, the impact of limited language proficiency as a reason for nonconsent among eligible patients is unknown.

Objectives: To determine the impact of language barrier as the primary reason for VTE research non-participation.

Methods: We reviewed all prospective VTE studies conducted at a research-intensive academic thrombosis research program in Canada between 2014 and 2024. Studies with screening logs that systematically and consecutively captured eligibility assessment and reasons for nonconsent were included. Primary outcome was nonconsent of a screen-eligible patient due to limited language proficiency as the reported reason. We derived pooled estimates of nonconsent due to limited language proficiency as a proportion of consented participants and determined subgroup rates by phase of VTE management, associated medical conditions, and recruitment settings.

Results: Screening logs of 28 studies with 22 057 screening events, 8317 screen-eligible patients, and 3320 consented participants were included. For every 100 consented participants, 3.2 (95% CI, 2.0-5.3) screen-eligible individuals were unable to provide consent due to limited language proficiency. Rates of nonconsent were highest in studies involving cancer (5.6 per 100 participants; 95% CI, 2.9-10.4) and in studies recruiting patients from ambulatory settings outside of the thrombosis clinic (10.8 per 100 participants; 95% CI, 4.8-22.6).

Conclusion: Language proficiency is a key barrier to VTE research participation. Urgent implementation of targeted interventions aimed at mitigating linguistic barriers is essential to ensure equitable opportunities for VTE research participation for racialized patients disproportionately affected by language proficiency.

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语言能力有限对参与静脉血栓栓塞症研究的影响:回顾性分析。
背景:语言能力有限是种族化人群参与研究的一个既定障碍。虽然之前的研究已经强调了种族化人群在静脉血栓栓塞症(VTE)研究中的代表性不足,但语言能力有限作为合格患者不同意研究的原因所产生的影响尚不清楚:我们回顾了 2014 年至 2024 年期间在加拿大一个研究密集型学术血栓研究项目中开展的所有前瞻性 VTE 研究。我们纳入了具有筛选日志的研究,这些日志系统、连续地记录了资格评估和未同意的原因。主要结果是符合筛查条件的患者因语言能力有限作为报告原因而未同意筛查。我们得出了因语言能力有限而未同意的参与者占同意参与者比例的汇总估计值,并根据 VTE 管理阶段、相关医疗条件和招募环境确定了亚组比率:共纳入了 28 项研究的筛查日志,涉及 22,057 个筛查事件、8,317 名符合筛查条件的患者和 3,320 名同意参与者。每 100 名同意的参与者中,就有 3.2 名(95% CI 2.0 - 5.3)符合筛查条件的人因语言能力有限而无法同意。在涉及癌症的研究(每 100 名参与者中有 5.6 人,95% CI 2.9 - 10.4)和招募血栓诊所以外流动环境患者的研究(每 100 名参与者中有 10.8 人,95% CI 4.8 - 22.6)中,未获同意的比例最高:语言能力是 VTE 研究参与的主要障碍。结论:语言能力是 VTE 研究参与的主要障碍。紧急实施旨在缓解语言障碍的针对性干预措施,对于确保受语言能力影响过大的种族化患者获得 VTE 研究参与的公平机会至关重要。
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来源期刊
Journal of Thrombosis and Haemostasis
Journal of Thrombosis and Haemostasis 医学-外周血管病
CiteScore
24.30
自引率
3.80%
发文量
321
审稿时长
1 months
期刊介绍: The Journal of Thrombosis and Haemostasis (JTH) serves as the official journal of the International Society on Thrombosis and Haemostasis. It is dedicated to advancing science related to thrombosis, bleeding disorders, and vascular biology through the dissemination and exchange of information and ideas within the global research community. Types of Publications: The journal publishes a variety of content, including: Original research reports State-of-the-art reviews Brief reports Case reports Invited commentaries on publications in the Journal Forum articles Correspondence Announcements Scope of Contributions: Editors invite contributions from both fundamental and clinical domains. These include: Basic manuscripts on blood coagulation and fibrinolysis Studies on proteins and reactions related to thrombosis and haemostasis Research on blood platelets and their interactions with other biological systems, such as the vessel wall, blood cells, and invading organisms Clinical manuscripts covering various topics including venous thrombosis, arterial disease, hemophilia, bleeding disorders, and platelet diseases Clinical manuscripts may encompass etiology, diagnostics, prognosis, prevention, and treatment strategies.
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