Central nervous system tumors in adolescents and young adults: A Society for Neuro-Oncology consensus review on diagnosis, management, and future directions.

IF 16.4 1区 医学 Q1 CLINICAL NEUROLOGY Neuro-oncology Pub Date : 2024-10-23 DOI:10.1093/neuonc/noae186
Mary Jane Lim-Fat, Julie Bennett, Quinn Ostrom, Mehdi Touat, Enrico Franceschi, Jessica Schulte, Ranjit S Bindra, Jason Fangusaro, Girish Dhall, James Nicholson, Sadhana Jackson, Tom Belle Davidson, Gabriele Calaminus, Giles Robinson, James R Whittle, Peter Hau, Vijay Ramaswamy, Kristian W Pajtler, Roberta Rudà, Nicholas K Foreman, Shawn L Hervey-Jumper, Sunit Das, Peter Dirks, Wenya Linda Bi, Annie Huang, Thomas E Merchant, Maryam Fouladi, Kenneth Aldape, Martin J Van den Bent, Roger J Packer, Julie J Miller, David A Reardon, Susan M Chang, Daphne Haas-Kogan, Uri Tabori, Cynthia Hawkins, Michelle Monje, Patrick Y Wen, Eric Bouffet, Kee Kiat Yeo
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Abstract

Adolescents and young adults (AYAs; ages 15-39 years) are a vulnerable population facing challenges in oncological care, including access to specialized care, transition of care, unique tumor biology, and poor representation in clinical trials. Brain tumors are the second most common tumor type in AYA, with malignant brain tumors being the most common cause of cancer-related death. The 2021 WHO Classification for central nervous system (CNS) Tumors highlights the importance of integrated molecular characterization with histologic diagnosis in several tumors relevant to the AYA population. In this position paper from the Society for Neuro-Oncology (SNO), the diagnosis and management of CNS tumors in AYA is reviewed, focusing on the most common tumor types in this population, namely glioma, medulloblastoma, ependymoma, and CNS germ cell tumor. Current challenges and future directions specific to AYA are also highlighted. Finally, possible solutions to address barriers in the care of AYA patients are discussed, emphasizing the need for multidisciplinary and collaborative approaches that span the pediatric and adult paradigms of care, and incorporating advanced molecular testing, targeted therapy, and AYA-centered care.

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青少年中枢神经系统肿瘤:神经肿瘤学会关于诊断、管理和未来方向的共识综述。
青少年和年轻成人(AYAs,15-39 岁)是一个脆弱的群体,他们在肿瘤治疗方面面临着各种挑战,包括获得专业治疗、治疗过渡、独特的肿瘤生物学特性以及在临床试验中的代表性较差。脑肿瘤是亚健康人群中第二常见的肿瘤类型,恶性脑肿瘤是癌症相关死亡的最常见原因。2021 年世界卫生组织(WHO)中枢神经系统(CNS)肿瘤分类强调了在与亚青人群相关的几种肿瘤中将分子特征描述与组织学诊断相结合的重要性。在这份由神经肿瘤学会(SNO)撰写的立场文件中,对青少年中枢神经系统肿瘤的诊断和管理进行了回顾,重点关注这一人群中最常见的肿瘤类型,即胶质瘤、髓母细胞瘤、外胚瘤和中枢神经系统生殖细胞瘤。此外,还重点介绍了针对青少年的当前挑战和未来发展方向。最后,还讨论了解决青少年患者治疗障碍的可能方案,强调需要多学科协作的方法,跨越儿科和成人的治疗模式,并结合先进的分子检测、靶向治疗和以青少年为中心的治疗。
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来源期刊
Neuro-oncology
Neuro-oncology 医学-临床神经学
CiteScore
27.20
自引率
6.30%
发文量
1434
审稿时长
3-8 weeks
期刊介绍: Neuro-Oncology, the official journal of the Society for Neuro-Oncology, has been published monthly since January 2010. Affiliated with the Japan Society for Neuro-Oncology and the European Association of Neuro-Oncology, it is a global leader in the field. The journal is committed to swiftly disseminating high-quality information across all areas of neuro-oncology. It features peer-reviewed articles, reviews, symposia on various topics, abstracts from annual meetings, and updates from neuro-oncology societies worldwide.
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