Topical Application of Centella asiatica in Wound Healing: Recent Insights into Mechanisms and Clinical Efficacy.

IF 4.9 3区医学 Q1 PHARMACOLOGY & PHARMACY Pharmaceutics Pub Date : 2024-09-26 DOI:10.3390/pharmaceutics16101252

Katarzyna Witkowska, Magdalena Paczkowska-Walendowska, Ewa Garbiec, Judyta Cielecka-Piontek

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Abstract

Centella asiatica, widely known as Gotu kola, is a traditional herb celebrated for its benefits in skin health and wound healing. Recent research has provided new insights into its efficacy, particularly through topical applications. This review highlights the plant's mechanisms, focusing on its active compounds such as asiaticoside, madecassoside, asiatic acid, and madecassic acid, which enhance collagen synthesis, modulate inflammation, and offer antioxidant protection. Clinical trials have been collected and summarized that innovative delivery systems, such as hydrogels, nanostructures or microneedles, can accelerate wound healing, reduce wound size, and improve recovery times in various wound types, including diabetic ulcers and burns. Future research will likely refine these technologies and explore new applications, reinforcing the role of C. asiatica in contemporary wound care. Advances in formulation and delivery will continue to enhance the plant's therapeutic potential, offering promising solutions for effective wound management.

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积雪草在伤口愈合中的局部应用：对机制和临床疗效的最新见解。

积雪草被广泛称为哥度柯拉，是一种传统草药，因其在皮肤健康和伤口愈合方面的功效而备受赞誉。最近的研究对其功效有了新的认识，特别是通过局部应用。这篇综述重点介绍了该植物的作用机制，重点是其活性化合物，如积雪草苷、积雪草甙、积雪草酸和积雪草酸，它们能促进胶原蛋白合成、调节炎症反应并提供抗氧化保护。收集和总结的临床试验表明，水凝胶、纳米结构或微针等创新给药系统可以加速伤口愈合，缩小伤口面积，并改善各种伤口（包括糖尿病溃疡和烧伤）的恢复时间。未来的研究很可能会完善这些技术并探索新的应用，从而加强积雪草在现代伤口护理中的作用。制剂和给药方面的进步将继续增强该植物的治疗潜力，为有效的伤口管理提供前景广阔的解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pharmaceutics Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

7.90

自引率

11.10%

发文量

2379

审稿时长

16.41 days

期刊介绍： Pharmaceutics (ISSN 1999-4923) is an open access journal which provides an advanced forum for the science and technology of pharmaceutics and biopharmaceutics. It publishes reviews, regular research papers, communications, and short notes. Covered topics include pharmacokinetics, toxicokinetics, pharmacodynamics, pharmacogenetics and pharmacogenomics, and pharmaceutical formulation. Our aim is to encourage scientists to publish their experimental and theoretical details in as much detail as possible. There is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced.