Effects of aged garlic extract on blood pressure in hypertensive patients: A systematic review and meta-analysis of randomized controlled trials

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2024-10-20 DOI:10.1016/j.prostaglandins.2024.106914

Mohamed J. Saadh , Muthena Kariem , Madhu Shukla , Suhas Ballal , Abhishek Kumar , Mamata Chahar , Suman Saini , Ish Kapila , Shirin Hasaanzadeh

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Abstract

Background

There is no consensus based on the existing literature regarding the effect of aged garlic extract (AGE) on blood pressure. The present systematic review and meta-analysis was conducted to synthesize existing data from randomized clinical trials (RCTs) concerning the impact of AGE supplementation on blood pressure in hypertensive patients.

Methods

We searched English web databases including, PubMed, Scopus, Embase, Web of Science until August 2024. Random-effects meta-analysis was used to pool weighted mean differences (WMD) and 95 % CI for the outcomes.

Results

Overall, nine RCTs with584 participants met inclusion criteria. AGE tea supplementation reduces systolic blood pressure (SBP) (WMD: −4.03; %95CI: −6.87, −1.20; I2: 57.1 %) and diastolic blood pressure (DBP) (WMD: −1.44; 95 % CI= −2.87, −0.02; P = 0.052; I²: 36.8 %; P: 0.105). Moreover, subgroup analysis indicated that higher doses of AGE supplementation in hypertensive patients significantly decreased DBP, and SBP.

Conclusion

The results of this study suggest that AGE supplements may be beneficial for improving blood pressure in hypertensive patients, but significant effects are observed only at doses over 1200 mg/day. To confirm these results, well-designed future trials will be needed.

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陈年大蒜提取物对高血压患者血压的影响：随机对照试验的系统回顾和荟萃分析。

背景：关于陈年大蒜提取物（AGE）对血压的影响，现有文献尚未达成共识。本系统综述和荟萃分析旨在综合现有随机临床试验（RCTs）中关于补充 AGE 对高血压患者血压影响的数据：我们检索了截至 2024 年 8 月的英文网络数据库，包括 PubMed、Scopus、Embase 和 Web of Science。采用随机效应荟萃分析法汇集结果的加权平均差（WMD）和 95% CI：共有9项研究符合纳入标准，584人参与研究。补充 AGE 茶可降低收缩压（SBP）（WMD：-4.03；95%CI：-6.87，-1.20；I2：57.1%）和舒张压（DBP）（WMD：-1.44；95%CI=-2.87，-0.02；P=0.052；I2：36.8%；P：0.105）。此外，亚组分析表明，高血压患者补充较高剂量的 AGE 可显著降低 DBP 和 SBP：本研究结果表明，AGE补充剂可能有益于改善高血压患者的血压，但只有在剂量超过1200毫克/天时才能观察到明显效果。要证实这些结果，还需要今后进行精心设计的试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.