Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP): what do we need to know?

IF 3.4 3区医学 Q1 PATHOLOGY Virchows Archiv Pub Date : 2024-10-23 DOI:10.1007/s00428-024-03953-y

Andrés Coca-Pelaz, Juan P Rodrigo, Abbas Agaimy, Dana M Hartl, Göran Stenman, Vincent Vander Poorten, Antti A Mäkitie, Mark Zafereo, Karthik N Rao, Gregory W Randolph, Alessandra Rinaldo, Alfio Ferlito

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Abstract

Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a recently defined thyroid nodule category characterized by follicular architecture with papillary nuclear features but lacking classical papillary carcinoma features like papillae or psammoma bodies. The diagnosis of NIFTP is based on histological examination and excludes cases with high-risk mutations like BRAFV600E. NIFTP carries a low risk of recurrence and distant metastasis, prompting a more conservative surgical approach compared to classical papillary thyroid carcinoma. The management of NIFTP typically involves lobectomy with postoperative monitoring of thyroglobulin levels and performing neck ultrasounds. While the identification of NIFTP represents a significant advancement in thyroid cancer diagnosis, challenges remain in refining preoperative diagnostic tools and establishing optimal long-term follow-up strategies. The objective of this review is to provide a comprehensive overview of NIFTP, including its histopathological characteristics, molecular profile, clinical presentation, diagnostic criteria, management strategies, and future research directions.

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具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）：我们需要了解什么？

具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP）是最近定义的甲状腺结节类别，其特征是具有乳头状核特征的滤泡结构，但缺乏经典的乳头状癌特征，如乳头状或脓肿体。NIFTP 的诊断基于组织学检查，排除了 BRAFV600E 等高风险突变的病例。NIFTP的复发和远处转移风险较低，因此与传统的甲状腺乳头状癌相比，NIFTP的手术方式更为保守。NIFTP的治疗方法通常是进行甲状腺叶切除术，术后监测甲状腺球蛋白水平并进行颈部超声检查。尽管NIFTP的发现标志着甲状腺癌诊断的重大进步，但在完善术前诊断工具和制定最佳长期随访策略方面仍存在挑战。本综述旨在全面概述 NIFTP，包括其组织病理学特征、分子特征、临床表现、诊断标准、管理策略和未来研究方向。

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来源期刊

Virchows Archiv 医学-病理学

CiteScore

7.40

自引率

2.90%

发文量

204

审稿时长

4-8 weeks

期刊介绍： Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.