Common Genetic Influence on the Relationship Between Gaming Addiction and Attention Deficit Hyperactivity Disorder in Young Adults: A Twin Study.

IF 1 4区医学 Q4 GENETICS & HEREDITY Twin Research and Human Genetics Pub Date : 2024-10-28 DOI:10.1017/thg.2024.29

Seol-Ah Lee, Yoon-Mi Hur

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Abstract

Although the relationship between gaming addiction (GA) and attention deficit hyperactivity disorder (ADHD) is well established, the causal mechanism of this relationship remains ambiguous. We aimed to investigate whether common genetic and/or environmental factors explain the GA-ADHD relationship. We recruited 1413 South Korean adult twins (837 monozygotic [MZ], 326 same-sex dizygotic [DZ], and 250 opposite-sex DZ twins; mean age = 23.1 ± 2.8 years) who completed an online survey on GA and related traits. Correlational analysis and bivariate model-fitting analysis were conducted. Phenotypic correlation between GA and ADHD in the present sample was 0.55 (95% CI [0.51, 0.59]). Bivariate model-fitting analysis revealed that genetic variances were 69% (95% CI [64%, 73%]) and 68% (95% CI [63%, 72%]) for ADHD and GA respectively. The remaining variances (ADHD: 31%; GA: 32%) were associated with nonshared environmental variances, including measurement error. Genetic and nonshared environmental correlations between ADHD and GA were 0.68 (95% CI [0.62, 0.74]) and 0.22 (95% CI [0.13, 0.30]) respectively, which indicates that shared genes can explain 82% of the phenotypic correlation between ADHD and GA. Our study demonstrated that the ADHD-GA association was largely due to shared genetic vulnerability.

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青少年游戏成瘾与注意力缺陷多动障碍之间的共同遗传影响：一项双胞胎研究。

尽管游戏成瘾（GA）与注意缺陷多动障碍（ADHD）之间的关系已经得到证实，但这种关系的因果机制仍然模糊不清。我们旨在研究共同的遗传和/或环境因素是否可以解释游戏成瘾与多动症之间的关系。我们招募了 1413 名韩国成年双胞胎（837 名单卵双生[MZ]，326 名同性双卵双生[DZ]，250 名异性双卵双生[DZ]；平均年龄 = 23.1 ± 2.8 岁），他们完成了关于 GA 及其相关特征的在线调查。研究人员进行了相关分析和双变量模型拟合分析。本样本中 GA 与多动症之间的表型相关性为 0.55（95% CI [0.51，0.59]）。双变量模型拟合分析显示，ADHD 和 GA 的遗传变异率分别为 69%（95% CI [64%，73%]）和 68%（95% CI [63%，72%]）。其余变异（ADHD：31%；GA：32%）与非共享环境变异有关，包括测量误差。ADHD和GA之间的遗传相关性和非共享环境相关性分别为0.68（95% CI [0.62，0.74]）和0.22（95% CI [0.13，0.30]），这表明共享基因可以解释ADHD和GA之间82%的表型相关性。我们的研究表明，ADHD与GA之间的关联在很大程度上是由共有的遗传易感性造成的。

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来源期刊

Twin Research and Human Genetics 医学-妇产科学

CiteScore

1.50

自引率

11.10%

发文量

审稿时长

6-12 weeks

期刊介绍： Twin Research and Human Genetics is the official journal of the International Society for Twin Studies. Twin Research and Human Genetics covers all areas of human genetics with an emphasis on twin studies, genetic epidemiology, psychiatric and behavioral genetics, and research on multiple births in the fields of epidemiology, genetics, endocrinology, fetal pathology, obstetrics and pediatrics. Through Twin Research and Human Genetics the society aims to publish the latest research developments in twin studies throughout the world.