Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study.

IF 3.8 3区 医学 Q2 CELL BIOLOGY Wound Repair and Regeneration Pub Date : 2024-10-23 DOI:10.1111/wrr.13229
Deyi Pan, Runqiao Yang, Yalan Zhang, Yuemei Chen, Yuhui Wang, Shixiong Xu
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Abstract

To gain a clearer understanding of the relationship between venous leg ulcers (VLUs) and knee osteoarthritis (KOA), we performed a two-sample, bidirectional Mendelian randomization (MR) analysis in this study. The present MR was carried out using summary data from publicly available genome-wide association studies. After filtering single-nucleotide polymorphism (SNP), we applied a variety of MR methods including inverse variance weighted (IVW), MR egger, weighted mode, and weighted median. IVW analysis revealed that the genetic association between VLUs and KOA was not significant (β = -0.017; SE 0.039; p = 0.658). In agreement with the IVW analysis, the findings of the weighted median estimator (β = -0.017; SE 0.052, p = 0.751), MR egger (β = 0.057; SE 0.084; p = 0.513), and weighted mode (β = 0.060; SE 0.078; p = 0.456) indicated the absence of a significant genetic association between VLUs and KOA. Furthermore, reverse causality analysis suggested a lack of genetic relationship between KOA and VLUs. In conclusion, the present MR study does not suggest a causal relationship or reverse causal relationship between VLUs and KOA.

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腿部静脉溃疡与膝关节骨性关节炎之间的关系:孟德尔随机研究
为了更清楚地了解腿部静脉溃疡(VLU)与膝骨关节炎(KOA)之间的关系,我们在本研究中进行了双样本、双向孟德尔随机化(MR)分析。本项孟德尔随机分析是利用公开的全基因组关联研究的汇总数据进行的。在筛选单核苷酸多态性(SNP)后,我们采用了多种 MR 方法,包括反方差加权(IVW)、MR egger、加权模式和加权中位数。IVW 分析显示,VLU 与 KOA 之间的遗传关联不显著(β = -0.017; SE 0.039; p = 0.658)。与 IVW 分析结果一致,加权中位数估计值(β = -0.017;SE 0.052,p = 0.751)、MR egger(β = 0.057;SE 0.084;p = 0.513)和加权模式(β = 0.060;SE 0.078;p = 0.456)的结果表明,VLU 与 KOA 之间不存在显著的遗传关联。此外,反向因果关系分析表明,KOA 和 VLU 之间缺乏遗传关系。总之,本磁共振研究并未表明 VLU 与 KOA 之间存在因果关系或反向因果关系。
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来源期刊
Wound Repair and Regeneration
Wound Repair and Regeneration 医学-皮肤病学
CiteScore
5.90
自引率
3.40%
发文量
71
审稿时长
6-12 weeks
期刊介绍: Wound Repair and Regeneration provides extensive international coverage of cellular and molecular biology, connective tissue, and biological mediator studies in the field of tissue repair and regeneration and serves a diverse audience of surgeons, plastic surgeons, dermatologists, biochemists, cell biologists, and others. Wound Repair and Regeneration is the official journal of The Wound Healing Society, The European Tissue Repair Society, The Japanese Society for Wound Healing, and The Australian Wound Management Association.
期刊最新文献
A novel method to assess photobiomodulation in stimulating regenerative capacity and vascularization in zebrafish. Recent advances in bioactive wound dressings. Comparing mechanical and enzymatic isolation procedures to isolate adipose-derived stromal vascular fraction: A systematic review. Association between venous leg ulcers and knee osteoarthritis: A Mendelian randomization study. Outcomes of dermal substitutes in burns and burn scar reconstruction: A systematic review and meta-analysis.
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