Spectroscopic Screening of Dexamethasone and Cyproheptadine Adulteration in Weight Gaining Products Marketed in Aden, Yemen.

Addiction and Health Pub Date : 2024-07-01 Epub Date: 2024-07-29 DOI:10.34172/ahj.1549

Wafa F S Badulla, Ebtesam S Bamahmood, Samah Hussein Banafa

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Abstract

Background: Weight-gaining (WG) products are either medicine or herbal products that have been used intensively by the young and adolescents in Yemen. These products may contain undeclared potentially toxic ingredients that can lead to several health problems and diseases on long-term usage. This study was intended to evaluate the presence of some undeclared pharmaceuticals, dexamethasone (DX) and cyproheptadine (CPR), in WG products in Aden, Yemen.

Methods: The detection of DX & CPR in WG products was evaluated using UV& Fourier transform infrared (FT-IR) spectroscopy. Also, phytochemical analysis was carried out for herbal products.

Findings: The study indicated the presence of CPR in Tab-II, honey mixture, and capsules in the range between 0.10%-102.6%. A lower percentage was detected in the honey mixture and a higher percentage in Tab-2. DX was only detected in Tab-I (102.87%).

Conclusion: It can be concluded that WG products may contain undeclared amounts of DX and CPR. Stricter regulations must be implemented for the usage and distribution of these products to avoid potential long-term adverse consequences.

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也门亚丁市场上销售的增重产品中地塞米松和赛庚啶掺假的光谱筛查。

背景：增重（WG）产品是也门青少年大量使用的药物或草药产品。这些产品可能含有未申报的潜在有毒成分，长期使用会导致多种健康问题和疾病。本研究旨在评估也门亚丁的 WG 产品中是否含有地塞米松（DX）和赛庚啶（CPR）等未申报药品：方法：使用紫外和傅立叶变换红外（FT-IR）光谱对 WG 产品中 DX 和 CPR 的检测进行评估。此外，还对草药产品进行了植物化学分析：研究表明，CPR 在 Tab-II、蜂蜜混合物和胶囊中的含量在 0.10%-102.6% 之间。在蜂蜜混合物中检测到的 CPR 百分比较低，而在 Tab-2 中检测到的 CPR 百分比较高。仅在 Tab-I 中检测到 DX（102.87%）：结论：可以得出结论，WG 产品可能含有未申报的 DX 和 CPR。必须对这些产品的使用和销售实施更严格的规定，以避免潜在的长期不良后果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Addiction and Health

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10 weeks