Environmental Stress-Induced Alterations in Embryo Developmental Morphokinetics.

IF 6.8 Q1 TOXICOLOGY Journal of Xenobiotics Pub Date : 2024-10-21 DOI:10.3390/jox14040087
Dorit Kalo, Shira Yaacobi-Artzi, Shir Manovich, Ariel Michaelov, Alisa Komsky-Elbaz, Zvi Roth
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Abstract

The association between embryo morphokinetics and its developmental competence is well documented. For instance, early cleaved embryos are more competent in developing to blastocysts, whereas the proportion of abnormally cleaved embryos that further developed to blastocysts is low. Numerous factors, such as the parental age, lifestyle, health, and smoking habits have been reported to affect the embryo morphokinetics and, consequently, its development. However, less is known about the effect of environmental stressors on embryo morphokinetics. The current review discusses the effect of the most concerning environmental stressors on embryo morphokinetics. These stresses include heat stress and human-made chemicals such as phthalates (e.g., bis-(2-ethylhexyl phthalate, dibutyl phthalate, dimethyl phthalate, and their primary metabolites), herbicides (e.g., diaminochlorotriazine, the primary metabolite of atrazine), pharmaceutical compounds (e.g., carbamazepine, nocodazole) and pro-oxidant agents (cumene hydroperoxide, Triton X-100), as well as naturally occurring toxins such as mycotoxin (e.g., aflatoxin B1 and its metabolite, and ochratoxin A). In addition, this review discusses the effect of ionizing or non-ionizing radiation and viral infections (e.g., SARS-CoV-2, papillomavirus). Finally, it points out some potential mechanisms that underlie the impairment of embryo morphokinetics, and it suggests protective compounds, mainly the supplementation of antioxidants to improve the morphokinetics, and consequently, the embryo developmental competence.

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环境压力引起的胚胎发育形态动力学变化
胚胎形态动力学与胚胎发育能力之间的关系有据可查。例如,早期裂解的胚胎更有能力发育成囊胚,而异常裂解的胚胎进一步发育成囊胚的比例较低。据报道,父母的年龄、生活方式、健康状况和吸烟习惯等众多因素都会影响胚胎的形态动力学,进而影响胚胎的发育。然而,人们对环境应激因素对胚胎形态动力学的影响知之甚少。本综述讨论了最常见的环境胁迫因素对胚胎形态动力学的影响。二氨基氯三嗪,阿特拉津的主要代谢物)、药物化合物(如卡马西平、硝基咪唑)和促氧化剂(过氧化氢积炭、Triton X-100),以及天然毒素,如霉菌毒素(如黄曲霉毒素 B1 及其代谢物和赭曲霉毒素 A)。此外,本综述还讨论了电离或非电离辐射以及病毒感染(如 SARS-CoV-2、乳头瘤病毒)的影响。最后,它指出了胚胎形态动力学受损的一些潜在机制,并提出了一些保护性化合物,主要是补充抗氧化剂,以改善形态动力学,从而提高胚胎发育能力。
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来源期刊
CiteScore
5.30
自引率
1.70%
发文量
21
审稿时长
10 weeks
期刊介绍: The Journal of Xenobiotics publishes original studies concerning the beneficial (pharmacology) and detrimental effects (toxicology) of xenobiotics in all organisms. A xenobiotic (“stranger to life”) is defined as a chemical that is not usually found at significant concentrations or expected to reside for long periods in organisms. In addition to man-made chemicals, natural products could also be of interest if they have potent biological properties, special medicinal properties or that a given organism is at risk of exposure in the environment. Topics dealing with abiotic- and biotic-based transformations in various media (xenobiochemistry) and environmental toxicology are also of interest. Areas of interests include the identification of key physical and chemical properties of molecules that predict biological effects and persistence in the environment; the molecular mode of action of xenobiotics; biochemical and physiological interactions leading to change in organism health; pathophysiological interactions of natural and synthetic chemicals; development of biochemical indicators including new “-omics” approaches to identify biomarkers of exposure or effects for xenobiotics.
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