Growth Parameters and Prevalence of Obesity in PKU Patients and Peers: Is This the Right Comparison?

IF 1.4 Q3 PEDIATRICS Pediatric Reports Pub Date : 2024-10-16 DOI:10.3390/pediatric16040076
Giulia Paterno, Vito Di Tullio, Rosa Carella, Giada De Ruvo, Fabrizio Furioso, Aleksandra Skublewska-D'Elia, Donatella De Giovanni, Albina Tummolo
{"title":"Growth Parameters and Prevalence of Obesity in PKU Patients and Peers: Is This the Right Comparison?","authors":"Giulia Paterno, Vito Di Tullio, Rosa Carella, Giada De Ruvo, Fabrizio Furioso, Aleksandra Skublewska-D'Elia, Donatella De Giovanni, Albina Tummolo","doi":"10.3390/pediatric16040076","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>One of the main objectives of Phenylketonuria (PKU) management is represented by optimising the growth trend under restricted protein diet regimen. The data on long-term growth in PKU children are limited and mostly based on earlier studies.</p><p><strong>Methods: </strong>The data for this twelve-year longitudinal study were collected from 34 PKU children and 37 healthy peers, whose auxological parameters were taken at 7 time-points over the follow-up. The weight-for-length ratio (WLR) z-score and body mass index (BMI) z-score were considered according to age. Prevalence of overweight/obesity was evaluated at last assessment.</p><p><strong>Results: </strong>The median BMI z-score of PKU children was normal and not statistically different from that of controls on all the seven time-point assessments. Their distributions tended to be wider than those of peers, with the upper limit exceeding the normal range since 12 months old, with a peak specifically at 3 years of age. In controls, there was a tendency to approach the BMI z-score values of overweight in later childhood. The prevalence of overweight was comparable (29% vs. 25%, <i>p</i>: 0.78) between the two groups at last assessment, and obese subjects (3/37) were only detected in the control group.</p><p><strong>Conclusions: </strong>In this study, we report data from a long-term follow-up on growth, highlighting that the median BMI z-score of PKU children was normal and not statistically different from that of controls. Also, the prevalence of obesity at 12 years of age was overlapping. However, the high prevalence of overweight children in the general population may explain the lack of difference and does not reassure about patients' nutritional risk.</p>","PeriodicalId":45251,"journal":{"name":"Pediatric Reports","volume":"16 4","pages":"892-901"},"PeriodicalIF":1.4000,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11503312/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Reports","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/pediatric16040076","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

Abstract

Background: One of the main objectives of Phenylketonuria (PKU) management is represented by optimising the growth trend under restricted protein diet regimen. The data on long-term growth in PKU children are limited and mostly based on earlier studies.

Methods: The data for this twelve-year longitudinal study were collected from 34 PKU children and 37 healthy peers, whose auxological parameters were taken at 7 time-points over the follow-up. The weight-for-length ratio (WLR) z-score and body mass index (BMI) z-score were considered according to age. Prevalence of overweight/obesity was evaluated at last assessment.

Results: The median BMI z-score of PKU children was normal and not statistically different from that of controls on all the seven time-point assessments. Their distributions tended to be wider than those of peers, with the upper limit exceeding the normal range since 12 months old, with a peak specifically at 3 years of age. In controls, there was a tendency to approach the BMI z-score values of overweight in later childhood. The prevalence of overweight was comparable (29% vs. 25%, p: 0.78) between the two groups at last assessment, and obese subjects (3/37) were only detected in the control group.

Conclusions: In this study, we report data from a long-term follow-up on growth, highlighting that the median BMI z-score of PKU children was normal and not statistically different from that of controls. Also, the prevalence of obesity at 12 years of age was overlapping. However, the high prevalence of overweight children in the general population may explain the lack of difference and does not reassure about patients' nutritional risk.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
PKU 患者与同龄人的生长参数和肥胖患病率:这样比较对吗?
背景:苯丙酮尿症(PKU)治疗的主要目标之一是在限制蛋白质饮食的情况下优化生长趋势。有关 PKU 儿童长期生长情况的数据十分有限,而且大多基于早期研究:这项为期 12 年的纵向研究收集了 34 名 PKU 儿童和 37 名健康儿童的数据,在随访期间的 7 个时间点采集了他们的辅助生长参数。体重身长比(WLR)z-分数和体重指数(BMI)z-分数根据年龄进行计算。在最后一次评估时对超重/肥胖的发生率进行了评估:结果:在所有七个时间点的评估中,PKU儿童的BMI z分数中位数均正常,与对照组相比没有统计学差异。他们的分布往往比同龄儿童更广,从12个月大开始,上限就超过了正常范围,特别是在3岁时达到高峰。在对照组中,儿童后期的体重指数 z 值有接近超重的趋势。在最后一次评估中,两组的超重率相当(29% 对 25%,P:0.78),只有对照组发现肥胖者(3/37):在这项研究中,我们报告了长期随访的生长数据,结果表明,PKU 儿童的体重指数 z 值中位数正常,与对照组相比没有统计学差异。此外,12岁时的肥胖率也有重叠。不过,一般人群中超重儿童的发病率很高,这可能是两者没有差异的原因,也不能让人对患者的营养风险放心。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
Pediatric Reports
Pediatric Reports PEDIATRICS-
CiteScore
2.10
自引率
0.00%
发文量
55
审稿时长
11 weeks
期刊最新文献
Parents' Knowledge and Attitudes Toward Pediatric Ophthalmic Disorders in Saudi Arabia: A Cross-Sectional Study. Respiratory Syncytial Virus in Pregnancy: An Obstetrics View. Growth Parameters and Prevalence of Obesity in PKU Patients and Peers: Is This the Right Comparison? Trends in Marijuana Use among Adolescents in the United States. Beyond Reading: Psychological and Mental Health Needs in Adolescents with Dyslexia.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1