Impact of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass.

IF 0.7 Q4 MEDICINE, RESEARCH & EXPERIMENTAL JOURNAL OF MEDICAL INVESTIGATION Pub Date : 2024-01-01 DOI:10.2152/jmi.71.210

Hideya Kashihara, Shohei Okikawa, Yuji Morine, Kozo Yoshikawa, Takuya Tokunaga, Masaaki Nishi, Chie Takasu, Mitsue Nishiyama, Makoto Zushi, Mitsuo Shimada

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Abstract

Introduction: We investigated the effect of Daikenchuto (TU-100) on the early postoperative period in duodenal-jejunal bypass (DJB).

Methods: Study 1:The effect of TU-100 on diabetic rats was investigated. Rats were sacrificed after receiving TU-100 for one week. Study 2:The effect of TU-100 on DJB was investigated. Rats in the DJB and TU-100 treated DJB groups were sacrificed 24 hours postoperation to evaluate blood glucose, cytokine expression, and gut microbiome.

Results: Study 1:TU-100 did not affect glucose or body weight. TU-100 suppressed intestinal inflammation and modified the gut microbiome. Specifically, Bifidobacterium and Blautia were increased, and Turicibacter were decreased in this group. Study 2:Both DJB and TU-100 treated DJB rats showed lower blood glucose at 24 hours postoperation than at preoperation. Cytokine expression in the liver and small intestine of the TU-100 treated DJB group was significantly lower than that of the DJB group. The gut microbiome composition in TU-100 treated DJB rats was altered. In particular, Bifidobacterium and Blautia were increased in this group.

Conclusion: DJB suppressed blood glucose during the early postoperative period. TU-100 may enhance the anti-diabetic effect of metabolic surgery by changing the gut microbiome and suppressing inflammation in the early postoperative period. J. Med. Invest. 71 : 210-218, August, 2024.

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Daikenchuto (TU-100)对十二指肠空肠旁路术术后早期的影响。

引言我们研究了 Daikenchuto（TU-100）对十二指肠空肠旁路术（DJB）术后早期的影响：研究 1：研究 TU-100 对糖尿病大鼠的影响。大鼠在接受 TU-100 治疗一周后被处死。研究 2：研究 TU-100 对 DJB 的影响。将 DJB 组和 TU-100 治疗 DJB 组的大鼠在手术后 24 小时处死，以评估血糖、细胞因子表达和肠道微生物组：研究 1：TU-100 不影响血糖和体重。TU-100 可抑制肠道炎症并改变肠道微生物组。具体来说，该组中的双歧杆菌和布劳氏菌增加，而湍流杆菌减少。研究 2：经 DJB 和 TU-100 治疗的 DJB 大鼠在术后 24 小时的血糖均低于术前。经 TU-100 处理的 DJB 组大鼠肝脏和小肠中细胞因子的表达量明显低于 DJB 组。经 TU-100 处理的 DJB 大鼠的肠道微生物群组成发生了改变。结论：结论：DJB 可抑制术后早期的血糖。结论：DJB 可抑制术后早期的血糖，TU-100 可通过改变肠道微生物群和抑制术后早期的炎症来增强代谢手术的抗糖尿病效果。J. Med.Invest.71 : 210-218, August, 2024.

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来源期刊

JOURNAL OF MEDICAL INVESTIGATION MEDICINE, RESEARCH & EXPERIMENTAL-

CiteScore

1.20

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0.00%

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