Eyelid skin and fibroadipose tissue MMP-1, MMP-3, TNF-α, and IL-6 levels in patients with inactive moderate-to-severe Graves' orbitopathy.

Pub Date : 2024-10-23 DOI:10.1080/01676830.2024.2414770

Nilay Yuksel, Ummuhani Ozel-Turkcu, Muslum Gok, Ozge Saritas, Bulent Yazici

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Abstract

Purpose: To evaluate matrix metalloprotease-1 (MMP-1), matrix metalloprotease-3 (MMP-3), tumor necrosis factor alpha (TNF-α), and interleukin-6 (IL-6) levels in the eyelid skin and fibroadipose tissue in patients with inactive moderate-to-severe Graves' orbitopathy (GO).

Methods: This prospective study included 23 patients with inactive moderate-to-severe GO who underwent upper blepharoplasty and medial fat excision, and 22 age- and sex-matched healthy subjects. MMP-1, MMP-3, TNF-α, and IL-6 levels in the skin and fibroadipose tissue obtained during surgery were measured using the ELISA method.

Results: The mean MMP-1 level in the eyelid skin (p = .003) and the mean MMP-3 level in the fibroadipose tissue (p = .04) were significantly lower in the GO group compared to the healthy control group. There were no differences in other mediators in both tissues between the two groups (p > .05).

Conclusions: The lower levels of proteolytic enzymes such as MMP-1 and MMP-3 in the eyelid skin and orbital fibroadipose tissue of patients with chronic inactive GO may play a role in the increase of collagen and glycosaminoglycans in orbital soft tissues.

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非活动性中重度巴塞杜氏眼眶病患者眼睑皮肤和纤维脂肪组织的 MMP-1、MMP-3、TNF-α 和 IL-6 水平。

目的：评估非活动性中重度巴塞杜氏眼眶病（GO）患者眼睑皮肤和纤维脂肪组织中基质金属蛋白酶-1（MMP-1）、基质金属蛋白酶-3（MMP-3）、肿瘤坏死因子α（TNF-α）和白细胞介素-6（IL-6）的水平：这项前瞻性研究包括23名接受了上眼睑成形术和内侧脂肪切除术的非活动性中重度GO患者，以及22名年龄和性别匹配的健康受试者。采用酶联免疫吸附法测定了手术中获得的皮肤和纤维脂肪组织中的 MMP-1、MMP-3、TNF-α 和 IL-6 水平：结果：与健康对照组相比，GO 组眼睑皮肤中的 MMP-1 平均水平（p = .003）和纤维脂肪组织中的 MMP-3 平均水平（p = .04）显著降低。两组组织中的其他介质没有差异（p > .05）：结论：慢性非活动性 GO 患者眼睑皮肤和眼眶纤维脂肪组织中的蛋白水解酶（如 MMP-1 和 MMP-3）水平较低，这可能是眼眶软组织中胶原蛋白和糖胺聚糖增加的原因之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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