Mass screening of hepatitis B and C in Burkina Faso: seroprevalence update and impact of hepatitis B vaccine.

IF 1.4 4区医学 Q4 INFECTIOUS DISEASES Journal of Infection in Developing Countries Pub Date : 2024-09-30 DOI:10.3855/jidc.19673

Armel Moumouni Sanou, Delphine Napon-Zongo, Abou Coulibaly, Ina Marie Angèle Traore, Ad Bafa Ibrahim Ouattara, Abdoul Kader Ilboudo, Abdou Azaque Zoure, Sylvie Zida, Mathuola Nina Geneviève Ouattara, Abdoulaye Dera, Djara Konate, Eric Kyelem, Achille Sindimbasba Nikiema, David Lankoande, Dieudonné Ilboudo, Dramane Kania

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Abstract

Introduction: Updated data on the seroprevalences of hepatitis B and C viruses (HBV, HCV) are required to enable the adaptation of control strategies. In this study, we aimed to: (i) estimate the seroprevalences of HBsAg carriers and HCV exposure in the general population, and (ii) determine the impact of vaccination on HBV circulation since its introduction in 2006 in the Expanded Program on Immunization (EPI).

Methodology: From October 2020 to October 2022, a mass screening campaign was conducted in 10 cities across Burkina Faso. Individuals of all ages and genders who consented to participate were screened for viral markers (HBsAg, anti-HCV) using rapid diagnostic tests. The proportions of HBsAg carriers and HCV exposure were calculated using Stata, and logistic regression was used to assess the impact of HBV vaccination on HBsAg carriage.

Results: A total of 15,650 participants were enrolled in the study. Of these, 51.4% were women and the age range was from 1 to 97 years. All participants were screened for HBsAg and 7,507 were also screened for anti-HCV. Overall, the seroprevalence of HBsAg was 8.8% and 2.6% for anti-HCV. The results indicated that age, gender, and place of residence were associated with HBV infection.

Conclusions: The prevalence of HBV and HCV infections remains high in Burkina Faso. Prevention strategies, including initial mass screening with rapid diagnostic tests and vaccination, need to be intensified.

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布基纳法索乙型肝炎和丙型肝炎大规模筛查：最新血清流行率和乙型肝炎疫苗的影响。

导言：需要有关乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）血清流行率的最新数据，以便调整控制策略。在这项研究中，我们的目标是(i) 估算普通人群中 HBsAg 携带者和 HCV 感染者的血清流行率；(ii) 确定自 2006 年扩大免疫计划 (EPI) 引入疫苗接种以来，疫苗接种对 HBV 传播的影响：方法：2020 年 10 月至 2022 年 10 月，在布基纳法索的 10 个城市开展大规模筛查活动。通过快速诊断检测对同意参与的所有年龄和性别的个人进行病毒标志物（HBsAg、抗-HCV）筛查。使用 Stata 计算了 HBsAg 携带者和 HCV 感染者的比例，并使用 Logistic 回归评估了接种 HBV 疫苗对 HBsAg 携带者的影响：共有 15,650 人参加了研究。其中 51.4% 为女性，年龄范围为 1 至 97 岁。所有参与者都接受了 HBsAg 筛查，7507 人还接受了抗-HCV 筛查。总体而言，HBsAg 血清阳性率为 8.8%，抗-HCV 血清阳性率为 2.6%。结果表明，年龄、性别和居住地与 HBV 感染有关：结论：布基纳法索的 HBV 和 HCV 感染率仍然很高。需要加强预防策略，包括使用快速诊断测试进行初步大规模筛查和接种疫苗。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Infection in Developing Countries INFECTIOUS DISEASES-

CiteScore

3.70

自引率

5.30%

发文量

239

审稿时长

4-8 weeks

期刊介绍： The Journal of Infection in Developing Countries (JIDC) is an international journal, intended for the publication of scientific articles from Developing Countries by scientists from Developing Countries. JIDC is an independent, on-line publication with an international editorial board. JIDC is open access with no cost to view or download articles and reasonable cost for publication of research artcles, making JIDC easily availiable to scientists from resource restricted regions.