Cell therapy in Sjögren's syndrome: opportunities and challenges.

IF 4.5 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Expert Reviews in Molecular Medicine Pub Date : 2024-10-23 DOI:10.1017/erm.2024.21
Yangyang Lu, Rongjing Shi, Wenqin He, Qi An, Jingwen Zhao, Xinnan Gao, Baiyan Zhang, Liyun Zhang, Ke Xu, Dan Ma
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Abstract

Sjögren's syndrome (SS) is a chronic autoimmune disease caused by immune system disorders. The main clinical manifestations of SS are dry mouth and eyes caused by the destruction of exocrine glands, such as the salivary and lacrimal glands, and systemic manifestations, such as interstitial pneumonia, interstitial nephritis and vasculitis. The pathogenesis of this condition is complex. However, this has not been fully elucidated. Treatment mainly consists of glucocorticoids, disease-modifying antirheumatic drugs and biological agents, which can only control inflammation but not repair the tissue. Therefore, identifying methods to regulate immune disorders and repair damaged tissues is imperative. Cell therapy involves the transplantation of autologous or allogeneic normal or bioengineered cells into the body of a patient to replace damaged cells or achieve a stronger immunomodulatory capacity to cure diseases, mainly including stem cell therapy and immune cell therapy. Cell therapy can reduce inflammation, relieve symptoms and promote tissue repair and regeneration of exocrine glands such as the salivary glands. It has broad application prospects and may become a new treatment strategy for patients with SS. However, there are various challenges in cell preparation, culture, storage and transportation. This article reviews the research status and prospects of cell therapies for SS.

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细胞疗法在斯约格伦综合征中的应用:机遇与挑战。
斯约格伦综合征(SS)是一种由免疫系统紊乱引起的慢性自身免疫性疾病。SS的主要临床表现是唾液腺和泪腺等外分泌腺受到破坏而引起的口干和眼干,以及间质性肺炎、间质性肾炎和血管炎等全身表现。这种疾病的发病机制十分复杂。然而,这一点尚未完全阐明。治疗方法主要包括糖皮质激素、改善病情抗风湿药物和生物制剂,但这些药物只能控制炎症,不能修复组织。因此,找到调节免疫紊乱和修复受损组织的方法势在必行。细胞疗法是指将自体或异体正常细胞或生物工程细胞移植到患者体内,以替代受损细胞或获得更强的免疫调节能力,从而达到治疗疾病的目的,主要包括干细胞疗法和免疫细胞疗法。细胞疗法可以减轻炎症,缓解症状,促进唾液腺等外分泌腺组织的修复和再生。它具有广阔的应用前景,有可能成为 SS 患者的一种新的治疗策略。然而,在细胞制备、培养、储存和运输方面存在各种挑战。本文回顾了细胞疗法治疗 SS 的研究现状和前景。
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来源期刊
Expert Reviews in Molecular Medicine
Expert Reviews in Molecular Medicine BIOCHEMISTRY & MOLECULAR BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL
CiteScore
7.40
自引率
1.60%
发文量
45
期刊介绍: Expert Reviews in Molecular Medicine is an innovative online journal featuring authoritative and timely Reviews covering gene therapy, immunotherapeutics, drug design, vaccines, genetic testing, pathogenesis, microbiology, genomics, molecular epidemiology and diagnostic techniques. We especially welcome reviews on translational aspects of molecular medicine, particularly those related to the application of new understanding of the molecular basis of disease to experimental medicine and clinical practice.
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