Association between iron deficiency anemia and severe maternal morbidity: A retrospective cohort study

IF 4.3 3区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC ACS Applied Electronic Materials Pub Date : 2024-10-21 DOI:10.1016/j.annepidem.2024.10.006

Samuel H. Nyarko PhD , Lucy T. Greenberg MS , George R. Saade MD , Ciaran S. Phibbs PhD , Jeffrey S. Buzas PhD , Scott A. Lorch MD , Jeannette Rogowski PhD , Molly Passarella MS , Nansi S. Boghossian PhD

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Abstract

Purpose

We examined the association between iron deficiency anemia (IDA) and severe maternal morbidity (SMM) during delivery and up to 1-year postpartum.

Methods

In a retrospective cohort study across 3 states, we computed adjusted relative risks (aRR) for SMM comparing individuals with IDA versus those without, using modified Poisson regression models.

Results

Among 2459,106 individuals, 10.3 % (n = 252,240) had IDA. Individuals with IDA experienced higher rates of blood transfusion and non-transfusion SMM (329 and 122 per 10,000 deliveries, respectively) than those without IDA (33 and 46 per 10,000 deliveries, respectively). The risk of blood transfusion (aRR: 8.2; 95 % CI 7.9–8.5) and non-transfusion SMM (aRR: 1.9; 95 % CI: 1.8–2.0) were higher among individuals with IDA. The attributable risk per 10,000 deliveries due to IDA for blood transfusion and non-transfusion SMM during delivery were 29.5 (95 % CI: 28.9–30.0) and 5.7 (95 % CI: 5.3–6.2), respectively. Within 1-year postpartum, the relative risk of non-transfusion SMM (aRR:1.3; 95 % CI: 1.2–1.3) was 30 % higher among individuals with IDA.

Conclusion

IDA is associated with increased SMM risk. Addressing IDA in pregnant individuals may reduce SMM rates.

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缺铁性贫血与孕产妇严重发病率之间的关系：一项回顾性队列研究。

目的：我们研究了缺铁性贫血（IDA）与分娩期及产后一年内严重孕产妇发病率（SMM）之间的关系：在一项横跨 3 个州的回顾性队列研究中，我们使用改进的泊松回归模型计算了缺铁性贫血患者与非缺铁性贫血患者的 SMM 调整相对风险系数 (aRR)：在 2459 106 人中，10.3%（n = 252 240）患有 IDA。IDA 患者输血和非输血 SMM 的发生率（分别为每万次分娩 329 例和 122 例）高于非 IDA 患者（分别为每万次分娩 33 例和 46 例）。IDA患者输血（aRR：8.2；95 % CI：7.9-8.5）和非输血SMM（aRR：1.9；95 % CI：1.8-2.0）的风险较高。因IDA而在分娩过程中输血和不输血SMM的每10,000例分娩的归因风险分别为29.5 (95 % CI: 28.9-30.0) 和5.7 (95 % CI: 5.3-6.2)。产后1年内，IDA患者发生非输血SMM的相对风险（aRR：1.3；95 % CI：1.2-1.3）高出30%：结论：IDA与SMM风险增加有关。结论：IDA 与 SMM 风险增加有关，解决孕妇的 IDA 问题可降低 SMM 发生率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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