Drug-associated glaucoma: A real-world study based on the Food and Drug Administration adverse event reporting system database.

IF 4.9 2区 医学 Q1 OPHTHALMOLOGY Clinical and Experimental Ophthalmology Pub Date : 2024-10-25 DOI:10.1111/ceo.14454
Shi-Nan Wu, Xiao-Dong Chen, Dan Yan, Yu-Qian Wang, Shao-Pan Wang, Wen-Ying Guan, Caihong Huang, Jiaoyue Hu, Zuguo Liu
{"title":"Drug-associated glaucoma: A real-world study based on the Food and Drug Administration adverse event reporting system database.","authors":"Shi-Nan Wu, Xiao-Dong Chen, Dan Yan, Yu-Qian Wang, Shao-Pan Wang, Wen-Ying Guan, Caihong Huang, Jiaoyue Hu, Zuguo Liu","doi":"10.1111/ceo.14454","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aims to assess the risk of drug-associated glaucoma and track its epidemiological characteristics using real-world data.</p><p><strong>Methods: </strong>Adverse event reports from the Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 to December 2023 were analysed. Disproportionality analysis and the Bayesian Confidence Propagation Neural Network algorithm were used. The study classified drugs associated with glaucoma, assessed risk levels, and compared drug-induced times across different categories.</p><p><strong>Results: </strong>Eight hundred and five drugs were linked to glaucoma in the FAERS database. Disproportionality analysis identified 46 drugs with significant risk, mainly adrenergic medications (clobetasol propionate, fluocinolone acetonide), antihypertensives (hydrochlorothiazide), insulin (insulin human), anticholinergics (umeclidinium, darifenacin), VEGF inhibitors (brolucizumab, faricimab), and psychotropics (topiramate, ziprasidone). The top three high-risk drugs were clobetasol propionate, umeclidinium, and fluocinolone acetonide. The shortest drug-induced times were observed with indacaterol, salmeterol, and umeclidinium. Anticholinergic medications had the shortest drug-induced time among all categories. Females (62.5%) and the elderly (average age 63.5 ± 16.8 years) were predominantly affected. Reports of drug-associated glaucoma increased over the years.</p><p><strong>Conclusion: </strong>Preventing drug-associated glaucoma is more effective than treatment. Identifying the risk and drug-induced times of systemic and ophthalmic drugs can reduce occurrence risk. Clinical practitioners should be vigilant and inform patients of these risks.</p>","PeriodicalId":55253,"journal":{"name":"Clinical and Experimental Ophthalmology","volume":null,"pages":null},"PeriodicalIF":4.9000,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical and Experimental Ophthalmology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/ceo.14454","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: This study aims to assess the risk of drug-associated glaucoma and track its epidemiological characteristics using real-world data.

Methods: Adverse event reports from the Food and Drug Administration Adverse Event Reporting System (FAERS) from January 2004 to December 2023 were analysed. Disproportionality analysis and the Bayesian Confidence Propagation Neural Network algorithm were used. The study classified drugs associated with glaucoma, assessed risk levels, and compared drug-induced times across different categories.

Results: Eight hundred and five drugs were linked to glaucoma in the FAERS database. Disproportionality analysis identified 46 drugs with significant risk, mainly adrenergic medications (clobetasol propionate, fluocinolone acetonide), antihypertensives (hydrochlorothiazide), insulin (insulin human), anticholinergics (umeclidinium, darifenacin), VEGF inhibitors (brolucizumab, faricimab), and psychotropics (topiramate, ziprasidone). The top three high-risk drugs were clobetasol propionate, umeclidinium, and fluocinolone acetonide. The shortest drug-induced times were observed with indacaterol, salmeterol, and umeclidinium. Anticholinergic medications had the shortest drug-induced time among all categories. Females (62.5%) and the elderly (average age 63.5 ± 16.8 years) were predominantly affected. Reports of drug-associated glaucoma increased over the years.

Conclusion: Preventing drug-associated glaucoma is more effective than treatment. Identifying the risk and drug-induced times of systemic and ophthalmic drugs can reduce occurrence risk. Clinical practitioners should be vigilant and inform patients of these risks.

查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
药物相关性青光眼:基于食品药品管理局不良事件报告系统数据库的真实世界研究。
背景:本研究旨在利用真实世界的数据评估药物相关性青光眼的风险并追踪其流行病学特征:本研究旨在利用真实世界的数据评估药物相关性青光眼的风险并追踪其流行病学特征:方法:分析食品药品管理局不良事件报告系统(FAERS)2004年1月至2023年12月的不良事件报告。采用了比例失调分析和贝叶斯置信度传播神经网络算法。研究对与青光眼有关的药物进行了分类,评估了风险水平,并比较了不同类别药物的诱发时间:结果:FAERS 数据库中有 85 种药物与青光眼有关。比例失调分析确定了46种具有重大风险的药物,主要是肾上腺素能药物(丙酸氯倍他索、氟西诺龙醋酸酯)、降压药(氢氯噻嗪)、胰岛素(人胰岛素)、抗胆碱能药物(乌甲素、达非那新)、血管内皮生长因子抑制剂(brolucizumab、法利西单抗)和精神药物(托吡酯、齐拉西酮)。前三种高风险药物是丙酸氯倍他索、乌甲素和氟西酮缩丙酮。茚达特罗、沙美特罗和乌美利铵的药效时间最短。在所有类别中,抗胆碱能药物的药物诱导时间最短。受影响的主要是女性(62.5%)和老年人(平均年龄为 63.5 ± 16.8 岁)。药物相关性青光眼的报告逐年增加:结论:预防药物性青光眼比治疗更有效。结论:预防药物性青光眼比治疗更有效。识别全身用药和眼科用药的风险和药物诱发时间可降低发生风险。临床医师应提高警惕,告知患者这些风险。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 去求助
来源期刊
CiteScore
7.60
自引率
12.50%
发文量
150
审稿时长
4-8 weeks
期刊介绍: Clinical & Experimental Ophthalmology is the official journal of The Royal Australian and New Zealand College of Ophthalmologists. The journal publishes peer-reviewed original research and reviews dealing with all aspects of clinical practice and research which are international in scope and application. CEO recognises the importance of collaborative research and welcomes papers that have a direct influence on ophthalmic practice but are not unique to ophthalmology.
期刊最新文献
Safety of and chorioretinal circulation during repeated low-level red-light therapy for myopic children. Aetiology and epidemiology of surgical vitreoretinal presentations in an Australian paediatric population: A seven-year retrospective study. In-vivo high-frequency quantitative ultrasound-derived parameters of the anterior sclera correlated with level of myopia and presence of staphyloma. Real world impact: Towards holistic analysis of author-level publication metrics. Axial length adjustment in eyes with silicone oil endotamponade reduces overestimation by a swept-source optical coherence tomography-based biometer.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1