Cellular Mechanisms of Lung Injury

IF 2.8 3区 医学 Q2 RESPIRATORY SYSTEM Clinics in Chest Medicine Pub Date : 2024-09-20 DOI:10.1016/j.ccm.2024.08.004
Jamie E. Meegan PhD , Alicia N. Rizzo MD, PhD , Eric P. Schmidt MD , Julie A. Bastarache MD
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肺损伤的细胞机制:当前视角。
肺泡-毛细血管屏障包括微血管内皮细胞和肺泡上皮细胞及其基质,它的破坏是急性呼吸窘迫综合征发病过程中肺损伤的关键驱动因素。在这篇综述中,我们概述了肺泡-毛细血管屏障在健康状态下的结构和功能,并强调了危重症期间导致内皮和上皮损伤的几种重要信号机制,同时强调了有可能开发针对肺泡-毛细血管渗漏的治疗策略的领域。我们还强调了生物标志物和临床前研究在开发新型疗法中的重要性,并着重指出了未来值得研究的重要领域。
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来源期刊
Clinics in Chest Medicine
Clinics in Chest Medicine 医学-呼吸系统
CiteScore
9.10
自引率
1.80%
发文量
87
审稿时长
6-12 weeks
期刊介绍: Clinics in Chest Medicine updates those in the fields of anesthesia, critical care, and respiratory medicine on the latest trends in patient management, providing a sound basis for choosing the best treatment options. Published quarterly—in March, June, September, and December—each issue offers state-of-the-art reviews on a single topic, including diseases of air movement and airways, infectious lung disease, pulmonary vascular disease, sleep-related disorders, respiratory failure, and systemic disease.
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