Extracellular vesicles from the dead: the final message.

IF 13 1区 生物学 Q1 CELL BIOLOGY Trends in Cell Biology Pub Date : 2024-10-21 DOI:10.1016/j.tcb.2024.09.005
Bo Shi, Thanh Kha Phan, Ivan K H Poon
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Abstract

Communication between dying and neighbouring cells is vital to ensure appropriate processes such as tissue repair or inflammation are initiated in response to cell death. As a mechanism to aid intercellular communication, cells undergoing apoptosis can release membrane-bound extracellular vesicles (EVs) called apoptotic-cell-derived EVs (ApoEVs) that can influence downstream processes through biomolecules within or on ApoEVs. ApoEVs are broadly categorised based on size as either large ApoEVs known as apoptotic bodies (ApoBDs) or small ApoEVs (s-ApoEVs). Notably, the mechanisms of ApoBD and s-ApoEV formation are different, and the functions of these two ApoEV subsets are distinct. This Review focuses on the biogenesis and functional properties of both ApoBDs and s-ApoEVs, particularly in the context of cell clearance, cell signalling and disease progression.

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来自死者的细胞外囊泡:最后的信息。
凋亡细胞与邻近细胞之间的交流对于确保在细胞死亡后启动组织修复或炎症等适当过程至关重要。作为一种帮助细胞间交流的机制,发生凋亡的细胞可释放出膜结合的胞外囊泡 (EV),这种囊泡被称为凋亡细胞衍生 EV(ApoEV),可通过 ApoEV 内或 ApoEV 上的生物大分子影响下游过程。ApoEVs根据大小大致分为被称为凋亡体(ApoBDs)的大型ApoEVs和小型ApoEVs(s-ApoEVs)。值得注意的是,ApoBD 和 s-ApoEV 的形成机制不同,这两种载脂蛋白EV 亚群的功能也各不相同。本综述将重点讨论 ApoBDs 和 s-ApoEVs 的生物生成和功能特性,尤其是在细胞清除、细胞信号传导和疾病进展方面。
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来源期刊
Trends in Cell Biology
Trends in Cell Biology 生物-细胞生物学
CiteScore
32.00
自引率
0.50%
发文量
160
审稿时长
61 days
期刊介绍: Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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