Retrospective Investigator-Initiated Trial on Tocopherol Acetate Vaginal Administration in Pre-and Postmenopausal Women.

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Diseases (Basel, Switzerland) Pub Date : 2024-10-02 DOI:10.3390/diseases12100237

Noemi Venditti, Giulio Petronio Petronio, Antonio Guarnieri, Laura Pietrangelo, Angela Spicciato, Alessio Colalillo, Giovanna Paola Sabusco, Dionisio Franco Barattini, Aldo Di Franco, Stefano Papini, Francesco Cosentino, Roberto Di Marco

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Abstract

Background: Menopause, a natural phase in a woman's life, often adversely affects physical, mental, sexual, and emotional well-being due to low estrogen levels. This study examines the impact of vaginal ovules with tocopherol acetate (Filme Gyno-V^® ovules, manufactured by Panin Srl and distributed by Hulka Srl, Italy), 500 mg per ovule, on vaginal health in pre- and menopausal women.

Methods: Fifty women aged 50-70 were divided into menopausal (28) and premenopausal (22) cohorts and treated with the ovules for two weeks, with assessments before and after treatment.

Results: The findings showed that distressing symptoms of vaginal atrophy, such as dryness, itching, and pain during intercourse, were resolved post-treatment. A molecular analysis revealed a reduction in Escherichia coli in both cohorts and an increase in three species of Lactobacillus in premenopausal patients.

Conclusions: This study concludes that Filme Gyno-V ovules may benefit vaginal health by alleviating atrophy symptoms and promoting healthy vaginal microbiota.

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由研究者发起的关于绝经前后妇女醋酸生育酚阴道给药的回顾性试验。

背景：更年期是女性一生中的一个自然阶段，由于雌激素水平低，更年期往往会对生理、心理、性和情感产生不利影响。本研究探讨了含醋酸生育酚的阴道卵泡（Filme Gyno-V® ovules，意大利 Panin Srl 公司生产，Hulka Srl 公司经销）（每粒 500 毫克）对绝经前和绝经期妇女阴道健康的影响：方法：将 50 名 50-70 岁的妇女分为绝经期（28 人）和绝经前（22 人）两组，用卵泡治疗两周，并在治疗前后进行评估：结果：研究结果表明，治疗后阴道干涩、瘙痒和性交疼痛等阴道萎缩的症状得到缓解。分子分析显示，两组患者体内的大肠杆菌均有所减少，绝经前患者体内的三种乳酸杆菌有所增加：本研究得出结论，Filme Gyno-V 胶囊可缓解阴道萎缩症状，促进阴道微生物群的健康，从而有益于阴道健康。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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